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Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Overview of attention for article published in Nature Genetics, March 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
13 news outlets
blogs
9 blogs
policy
1 policy source
twitter
36 X users
patent
4 patents
facebook
3 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
1 Google+ user

Citations

dimensions_citation
285 Dimensions

Readers on

mendeley
437 Mendeley
citeulike
5 CiteULike
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Title
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Published in
Nature Genetics, March 2015
DOI 10.1038/ng.3246
Pubmed ID
Authors

Stacy Steinberg, Hreinn Stefansson, Thorlakur Jonsson, Hrefna Johannsdottir, Andres Ingason, Hannes Helgason, Patrick Sulem, Olafur Th Magnusson, Sigurjon A Gudjonsson, Unnur Unnsteinsdottir, Augustine Kong, Seppo Helisalmi, Hilkka Soininen, James J Lah, Dag Aarsland, Tormod Fladby, Ingun D Ulstein, Srdjan Djurovic, Sigrid B Sando, Linda R White, Gun-Peggy Knudsen, Lars T Westlye, Geir Selbæk, Ina Giegling, Harald Hampel, Mikko Hiltunen, Allan I Levey, Ole A Andreassen, Dan Rujescu, Palmi V Jonsson, Sigurbjorn Bjornsson, Jon Snaedal, Kari Stefansson

Abstract

We conducted a search for rare, functional variants altering susceptibility to Alzheimer's disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in Icelanders (odds ratio (OR) = 2.12, P = 2.2 × 10(-13)) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03, P = 6.8 × 10(-15)).

X Demographics

X Demographics

The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 437 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
United Kingdom 2 <1%
Italy 2 <1%
Germany 1 <1%
Switzerland 1 <1%
Norway 1 <1%
France 1 <1%
Belgium 1 <1%
Canada 1 <1%
Other 2 <1%
Unknown 422 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 100 23%
Student > Ph. D. Student 95 22%
Student > Master 42 10%
Student > Bachelor 36 8%
Other 23 5%
Other 67 15%
Unknown 74 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 118 27%
Biochemistry, Genetics and Molecular Biology 68 16%
Neuroscience 51 12%
Medicine and Dentistry 50 11%
Computer Science 9 2%
Other 41 9%
Unknown 100 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 196. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2023.
All research outputs
#204,789
of 25,837,817 outputs
Outputs from Nature Genetics
#333
of 7,639 outputs
Outputs of similar age
#2,211
of 281,181 outputs
Outputs of similar age from Nature Genetics
#5
of 81 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.