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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
|
|---|---|
| Published in |
Nature Communications, March 2015
|
| DOI | 10.1038/ncomms7548 |
| Pubmed ID | |
| Authors |
Simon Junankar, Laura A. Baker, Daniel L. Roden, Radhika Nair, Ben Elsworth, David Gallego-Ortega, Paul Lacaze, Aurélie Cazet, Iva Nikolic, Wee Siang Teo, Jessica Yang, Andrea McFarland, Kate Harvey, Matthew J. Naylor, Sunil R. Lakhani, Peter T. Simpson, Ashwini Raghavendra, Jodi Saunus, Jason Madore, Warren Kaplan, Christopher Ormandy, Ewan K. A. Millar, Sandra O’Toole, Kyuson Yun, Alexander Swarbrick |
| Abstract |
Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a putative mammary basal cell of origin. Using an ID4GFP knock-in reporter mouse and single-cell transcriptomics, we show that ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation. Furthermore, ID4 is specifically expressed by a subset of human BLBC that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell. These studies identify ID4 as a mammary stem cell regulator, deconvolute the heterogeneity of BLBC and link a subset of mammary stem cells to the aetiology of BLBC. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 25% |
| United States | 1 | 13% |
| Canada | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 38% |
| Science communicators (journalists, bloggers, editors) | 3 | 38% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 62 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 21% |
| Researcher | 13 | 21% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 4 | 6% |
| Student > Doctoral Student | 3 | 5% |
| Other | 9 | 14% |
| Unknown | 12 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 33% |
| Biochemistry, Genetics and Molecular Biology | 20 | 32% |
| Medicine and Dentistry | 4 | 6% |
| Engineering | 2 | 3% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 12 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2015.
All research outputs
#533,566
of 24,276,163 outputs
Outputs from Nature Communications
#9,188
of 51,725 outputs
Outputs of similar age
#6,651
of 267,747 outputs
Outputs of similar age from Nature Communications
#89
of 767 outputs
Altmetric has tracked 24,276,163 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,725 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.3. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,747 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 767 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.