| Title |
Association of cerebrospinal fluid Neurogranin with Alzheimer’s disease
|
|---|---|
| Published in |
Aging Clinical and Experimental Research, April 2018
|
| DOI | 10.1007/s40520-018-0948-3 |
| Pubmed ID | |
| Authors |
Lijun Wang, for the Alzheimer’s Disease Neuroimaging Initiative |
| Abstract |
Cerebrospinal fluid (CSF) Neurogranin has recently been proposed as a potential biomarker for cognitive decline and brain injury in Alzheimer's disease (AD). To test whether CSF Neurogranin levels are increased in AD and its association with cognitive decline, we examined 99 cognitively normal (CN) subjects, 171 patients with mild cognitive impairment (MCI), and 81 patients with AD in the cross-sectional study from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The results showed that CSF Neurogranin was increased in both AD and MCI compared with controls. CSF Neurogranin was particularly high in patients with MCI and AD dementia with Aβ pathologic features. Neurogranin levels were significantly higher in females compared to males with MCI. Levels of Neurogranin between the males and females with AD and CN did not differ. Neurogranin levels were significantly higher in APOE ε4 carriers compared to APOE ε4 non-carriers with MCI. Levels of Neurogranin between the APOE ε4 carriers and APOE ε4 non-carriers with AD and CN did not differ. Elevated CSF Neurogranin levels were positively correlated with levels of total tau and P-tau in AD. The results indicated that CSF Neurogranin was increased at the prodromal stage of AD and might reflect synaptic injury as cognitive decline in AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 23% |
| Student > Master | 7 | 13% |
| Student > Postgraduate | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Researcher | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Psychology | 4 | 8% |
| Agricultural and Biological Sciences | 4 | 8% |
| Materials Science | 2 | 4% |
| Other | 8 | 15% |
| Unknown | 22 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2018.
All research outputs
#4,838,109
of 25,382,440 outputs
Outputs from Aging Clinical and Experimental Research
#380
of 1,867 outputs
Outputs of similar age
#87,732
of 340,618 outputs
Outputs of similar age from Aging Clinical and Experimental Research
#9
of 29 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,867 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,618 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.