Title |
Intravenous Therapy Duration and Outcomes in Melioidosis: A New Treatment Paradigm
|
---|---|
Published in |
PLoS Neglected Tropical Diseases, March 2015
|
DOI | 10.1371/journal.pntd.0003586 |
Pubmed ID | |
Authors |
Matthew C. Pitman, Tara Luck, Catherine S. Marshall, Nicholas M. Anstey, Linda Ward, Bart J. Currie |
Abstract |
International melioidosis treatment guidelines recommend a minimum 10 to 14 days' intravenous antibiotic therapy (intensive phase), followed by 3 to 6 months' oral therapy (eradication phase). This approach is associated with rates of relapse, defined as recurrence following the eradication phase, that can exceed 5%. Rates of recrudescence, defined as recurrence during the eradication phase, have not previously been reported. In response to low eradication phase completion rates in Australia, a local guideline has evolved over the last ten years recommending a longer minimum intensive phase duration for many cases of melioidosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 10 | 14% |
Student > Postgraduate | 10 | 14% |
Student > Ph. D. Student | 9 | 12% |
Student > Bachelor | 8 | 11% |
Student > Master | 8 | 11% |
Other | 14 | 19% |
Unknown | 14 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 36% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Agricultural and Biological Sciences | 5 | 7% |
Immunology and Microbiology | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 11 | 15% |
Unknown | 18 | 25% |