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Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation

Overview of attention for article published in The Journal of Immunology, May 2015
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Title
Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation
Published in
The Journal of Immunology, May 2015
DOI 10.4049/jimmunol.1400909
Pubmed ID
Authors

Shen Yun Foo, Vivian Zhang, Amit Lalwani, Jason P Lynch, Aowen Zhuang, Chuan En Lam, Paul S Foster, Cecile King, Raymond J Steptoe, Stuart B Mazzone, Peter D Sly, Simon Phipps

Abstract

Inducible BALT (iBALT) can amplify pulmonary or systemic inflammatory responses to the benefit or detriment of the host. We took advantage of the age-dependent formation of iBALT to interrogate the underlying mechanisms that give rise to this ectopic, tertiary lymphoid organ. In this study, we show that the reduced propensity for weanling as compared with neonatal mice to form iBALT in response to acute LPS exposure is associated with greater regulatory T cell expansion in the mediastinal lymph nodes. Ab- or transgene-mediated depletion of regulatory T cells in weanling mice upregulated the expression of IL-17A and CXCL9 in the lungs, induced a tissue neutrophilia, and increased the frequency of iBALT to that observed in neonatal mice. Remarkably, neutrophil depletion in neonatal mice decreased the expression of the B cell active cytokines, a proliferation-inducing ligand and IL-21, and attenuated LPS-induced iBALT formation. Taken together, our data implicate a role for neutrophils in lymphoid neogenesis. Neutrophilic inflammation is a common feature of many autoimmune diseases in which iBALT are present and pathogenic, and hence the targeting of neutrophils or their byproducts may serve to ameliorate detrimental lymphoid neogenesis in a variety of disease contexts.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 31%
Researcher 10 17%
Student > Bachelor 6 10%
Student > Master 6 10%
Student > Doctoral Student 4 7%
Other 7 12%
Unknown 7 12%
Readers by discipline Count As %
Immunology and Microbiology 20 34%
Biochemistry, Genetics and Molecular Biology 9 16%
Agricultural and Biological Sciences 9 16%
Medicine and Dentistry 8 14%
Engineering 2 3%
Other 3 5%
Unknown 7 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2015.
All research outputs
#20,941,392
of 23,567,572 outputs
Outputs from The Journal of Immunology
#27,075
of 27,977 outputs
Outputs of similar age
#224,063
of 265,795 outputs
Outputs of similar age from The Journal of Immunology
#236
of 282 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27,977 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,795 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 282 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.