| Title |
The role of morphine in regulation of cancer cell growth
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, July 2011
|
| DOI | 10.1007/s00210-011-0672-4 |
| Pubmed ID | |
| Authors |
Katarzyna Gach, Anna Wyrębska, Jakub Fichna, Anna Janecka |
| Abstract |
Morphine is considered the "gold standard" for relieving pain and is currently one of the most effective drugs available clinically for the management of severe pain associated with cancer. In addition to its use in the treatment of pain, morphine appears to be important in the regulation of neoplastic tissue. Although morphine acts directly on the central nervous system to relieve pain, its activities on peripheral tissues are responsible for many of the secondary complications. Therefore, understanding the impact, other than pain control, of morphine on cancer treatment is extremely important. The effect of morphine on tumor growth is still contradictory, as both growth-promoting and growth-inhibiting effects have been observed. Accumulating evidence suggests that morphine can affect proliferation and migration of tumor cells as well as angiogenesis. Various signaling pathways have been suggested to be involved in these extra-analgesic effects of morphine. Suppression of immune system by morphine is an additional complication. This review provides an update on the influence of morphine on the growth and migration potential of tumor cells. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Sweden | 1 | <1% |
| Czechia | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 111 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 15% |
| Student > Master | 16 | 14% |
| Student > Bachelor | 15 | 13% |
| Researcher | 12 | 10% |
| Other | 8 | 7% |
| Other | 19 | 17% |
| Unknown | 28 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 27% |
| Agricultural and Biological Sciences | 14 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
| Chemistry | 7 | 6% |
| Other | 12 | 10% |
| Unknown | 33 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
All research outputs
#6,375,151
of 22,653,392 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#307
of 1,718 outputs
Outputs of similar age
#35,551
of 119,429 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#4
of 8 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,718 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,429 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.