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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
|
|---|---|
| Published in |
Nature Immunology, March 2015
|
| DOI | 10.1038/ni.3132 |
| Pubmed ID | |
| Authors |
Matthew S Miller, Alexander Rialdi, Jessica Sook Yuin Ho, Micah Tilove, Luis Martinez-Gil, Natasha P Moshkina, Zuleyma Peralta, Justine Noel, Camilla Melegari, Ana M Maestre, Panagiotis Mitsopoulos, Joaquín Madrenas, Sven Heinz, Chris Benner, John A T Young, Alicia R Feagins, Christopher F Basler, Ana Fernandez-Sesma, Olivier J Becherel, Martin F Lavin, Harm van Bakel, Ivan Marazzi |
| Abstract |
The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Germany | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Korea, Republic of | 1 | <1% |
| Unknown | 115 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 24% |
| Student > Ph. D. Student | 18 | 15% |
| Student > Bachelor | 17 | 14% |
| Student > Master | 14 | 12% |
| Professor | 7 | 6% |
| Other | 20 | 17% |
| Unknown | 15 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 27% |
| Biochemistry, Genetics and Molecular Biology | 31 | 26% |
| Medicine and Dentistry | 13 | 11% |
| Immunology and Microbiology | 9 | 8% |
| Neuroscience | 4 | 3% |
| Other | 9 | 8% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 94. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2015.
All research outputs
#378,326
of 22,796,179 outputs
Outputs from Nature Immunology
#253
of 3,794 outputs
Outputs of similar age
#4,854
of 263,906 outputs
Outputs of similar age from Nature Immunology
#1
of 45 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,794 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.