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Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project

Overview of attention for article published in EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, March 2015
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Title
Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project
Published in
EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, March 2015
DOI 10.1289/ehp.1408224
Pubmed ID
Authors

Timo Lanki, Regina Hampel, Pekka Tiittanen, Silke Andrich, Rob Beelen, Bert Brunekreef, Julia Dratva, Ulf De Faire, Kateryna B. Fuks, Barbara Hoffmann, Medea Imboden, Pekka Jousilahti, Wolfgang Koenig, Amir A. Mahabadi, Nino Künzli, Nancy L. Pedersen, Johanna Penell, Göran Pershagen, Nicole M. Probst-Hensch, Emmanuel Schaffner, Christian Schindler, Dorothea Sugiri, Wim J.R. Swart, Ming-Yi Tsai, Anu W. Turunen, Gudrun Weinmayr, Kathrin Wolf, Tarja Yli-Tuomi, Annette Peters

Abstract

Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. This study evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease. Six cohorts of adults from Central and Northern Europe were used in this cross-sectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation, high-sensitive C-reactive protein (CRP) and fibrinogen, were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants' long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure. Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (>10,000 vehicles/day) road had elevated CRP values (10.2%, 95% CI 2.4-18.8%, compared to persons living in a quiet residential street with less than 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%, 95% CI 0.3-6.1 per 20 µg/m(3)), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed. Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Sweden 1 <1%
France 1 <1%
Germany 1 <1%
Unknown 120 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 17%
Researcher 18 14%
Student > Doctoral Student 12 10%
Student > Bachelor 10 8%
Other 9 7%
Other 21 17%
Unknown 34 27%
Readers by discipline Count As %
Environmental Science 24 19%
Medicine and Dentistry 23 18%
Nursing and Health Professions 7 6%
Agricultural and Biological Sciences 5 4%
Economics, Econometrics and Finance 3 2%
Other 20 16%
Unknown 43 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2015.
All research outputs
#22,834,739
of 25,460,914 outputs
Outputs from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#8,210
of 8,435 outputs
Outputs of similar age
#239,779
of 278,204 outputs
Outputs of similar age from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#82
of 88 outputs
Altmetric has tracked 25,460,914 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,435 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,204 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.