| Title |
Expression of the Flp proteins by Haemophilus ducreyiis necessary for virulence in human volunteers
|
|---|---|
| Published in |
BMC Microbiology, September 2011
|
| DOI | 10.1186/1471-2180-11-208 |
| Pubmed ID | |
| Authors |
Diane M Janowicz, Sean A Cooney, Jessica Walsh, Beth Baker, Barry P Katz, Kate R Fortney, Beth W Zwickl, Sheila Ellinger, Robert S Munson |
| Abstract |
Haemophilus ducreyi, the causative agent of the sexually transmitted disease chancroid, contains a flp (fimbria like protein) operon that encodes proteins predicted to contribute to adherence and pathogenesis. H. ducreyi mutants that lack expression of Flp1 and Flp2 or TadA, which has homology to NTPases of type IV secretion systems, have decreased abilities to attach to and form microcolonies on human foreskin fibroblasts (HFF). A tadA mutant is attenuated in its ability to cause disease in human volunteers and in the temperature dependent rabbit model, but a flp1flp2 mutant is virulent in rabbits. Whether a flp deletion mutant would cause disease in humans is not clear. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 200% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 5% |
| India | 1 | 5% |
| Unknown | 20 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 27% |
| Student > Ph. D. Student | 4 | 18% |
| Researcher | 3 | 14% |
| Student > Master | 3 | 14% |
| Student > Doctoral Student | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 45% |
| Biochemistry, Genetics and Molecular Biology | 4 | 18% |
| Immunology and Microbiology | 1 | 5% |
| Medicine and Dentistry | 1 | 5% |
| Neuroscience | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2012.
All research outputs
#15,866,607
of 23,577,654 outputs
Outputs from BMC Microbiology
#1,797
of 3,260 outputs
Outputs of similar age
#92,419
of 132,132 outputs
Outputs of similar age from BMC Microbiology
#16
of 18 outputs
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