| Title |
Changes of Brain Structure and Function in ADHD Children
|
|---|---|
| Published in |
Brain Topography, December 2010
|
| DOI | 10.1007/s10548-010-0168-4 |
| Pubmed ID | |
| Authors |
Ming-guo Qiu, Zhang Ye, Qi-yu Li, Guang-jiu Liu, Bing Xie, Jian Wang |
| Abstract |
To explore the changes of brain structure and function in attention-deficit/hyperactivity disorder (ADHD), fifteen ADHD patients (inattention subtype) and 15 normal control participants were recruited, the brain structure and function of these subjects were investigated by combining structural magnetic resonance imaging (MRI), diffusion tensor imaging and resting-state functional MRI. The results showed that ADHD patients had a significant decrease in the volume of the white matter (P = 0.04), and a trend toward decreased volume of brain structures except for the putamen and globus pallidus. The visualization of statistical difference maps of the cortical thickness showed that ADHD patients had focal thinning in bilateral frontal regions and the right cingulate cortex (P < 0.05 uncorrected, except for a cluster threshold of 10 voxels). Statistical analysis of the FA maps revealed that ADHD patients had significantly decreased FA in the forceps minor, the internal capsule, the corona radiata, the splenium of the corpus callosum, and the bilateral basal ganglia (P < 0.05 uncorrected as above). ADHD patients had significantly decreased functional connectivity in the anterior cingulate cortex, posterior cingulate cortex, lateral prefrontal cortex, left precuneus and thalamus, but increased functional connectivity in bilateral posterior medial frontal cortex in the default mode network (P < 0.05 uncorrected as above). Our results provide new insights into the changes of the brain structure and function in ADHD, which suggests that alterations in the brain structural and functional connectivity might implicate the pathophysiology of ADHD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 329 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Netherlands | 2 | <1% |
| Brazil | 1 | <1% |
| Taiwan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 319 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 19% |
| Student > Master | 45 | 14% |
| Researcher | 44 | 13% |
| Student > Bachelor | 44 | 13% |
| Student > Doctoral Student | 16 | 5% |
| Other | 52 | 16% |
| Unknown | 66 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 84 | 26% |
| Neuroscience | 48 | 15% |
| Medicine and Dentistry | 40 | 12% |
| Agricultural and Biological Sciences | 28 | 9% |
| Engineering | 11 | 3% |
| Other | 35 | 11% |
| Unknown | 83 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2021.
All research outputs
#3,095,883
of 22,653,392 outputs
Outputs from Brain Topography
#40
of 483 outputs
Outputs of similar age
#19,439
of 180,367 outputs
Outputs of similar age from Brain Topography
#1
of 1 outputs
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