Title |
Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia
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Published in |
Stem Cell Research & Therapy, September 2011
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DOI | 10.1186/scrt79 |
Pubmed ID | |
Authors |
Jung Yeon Lim, Chang Hyun Jeong, Jin Ae Jun, Seong Muk Kim, Chung Heon Ryu, Yun Hou, Wonil Oh, Jong Wook Chang, Sin-Soo Jeun |
Abstract |
Stem cell transplantation is a promising therapeutic strategy for the treatment of stroke. Mesenchymal stem cells (MSCs) are a potential cell source for clinical application because they can be easily obtained and cultivated with a high proliferative capacity. The safety and efficacy of cell therapy depends on the mode of cell administration. To determine the therapeutic potential of intrathecal administration of MSCs by lumbar puncture (LP), we administrated human umbilical cord blood-derived MSCs (hUCB-MSCs) intrathecally into the lumbar spinal cord or intravenously into the tail vein in a rat model of stroke, and then investigated whether hUCB-MSCs could enter the brain, survive, and improve post-stroke neurological functional recovery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Iran, Islamic Republic of | 1 | 1% |
United Kingdom | 1 | 1% |
Korea, Republic of | 1 | 1% |
Unknown | 85 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 16% |
Student > Bachelor | 14 | 16% |
Student > Ph. D. Student | 13 | 15% |
Student > Master | 13 | 15% |
Other | 5 | 6% |
Other | 17 | 19% |
Unknown | 12 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 25 | 28% |
Medicine and Dentistry | 24 | 27% |
Engineering | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 10 | 11% |
Unknown | 16 | 18% |