| Title |
Epidemiology, antibiotic consumption and molecular characterisation of Staphylococcus aureus infections – data from the Polish Neonatology Surveillance Network, 2009–2012
|
|---|---|
| Published in |
BMC Infectious Diseases, April 2015
|
| DOI | 10.1186/s12879-015-0890-3 |
| Pubmed ID | |
| Authors |
Dorota Romaniszyn, Anna Różańska, Jadwiga Wójkowska-Mach, Agnieszka Chmielarczyk, Monika Pobiega, Paweł Adamski, Ewa Helwich, Ryszard Lauterbach, Maria Borszewska-Kornacka, Ewa Gulczyńska, Agnieszka Kordek, Małgorzata Bulanda |
| Abstract |
Our aim was to determine and characterize S. aureus (SA) isolated from infections in newborns for antibiotic resistance, virulence factors, genotypes, epidemiology and antibiotic consumption. Prospective surveillance of infections was conducted. Data about antibiotic treatment were analyzed. Antimicrobial susceptibility was assessed. PCR amplification was used to detect resistance and virulence genes. Typing methods such as PFGE, spa-typing and SCCmec were used. SA was found to be associated with 6.5% of infections. Methicillin-Resistant Staphylococcus aureus accounted for 32.8% of SA-infections. An incidence of MRSA-infections was 1.1/1000 newborns. MRSA-infections were diagnosed significantly earlier than MSSA-infections in these newborns (14th day vs. 23rd day (p = 0.0194)). MRSA-infections increased the risk of newborn's death. Antibiotic consumption in both group was similar, but a high level of glycopeptides-usage for MSSA infections was observed. In the MRSA group, more strains were resistant to erythromycin, clindamycin, gentamicin and amikacin than in the MSSA group. Hla gene was present in 93.9% of strains, and seg and sei in 65.3% of strains, respectively. One dominant clone was found among the 14 MRSA isolates. Fifteen strains belonging to SCCmec type IV were spa-t015 and one strain belonging to SCCmec type V was spa-t011. Results obtained in the study point at specific epidemiological situation in Polish NICU (more detailed studies are recommended). High usage of glycopeptides in the MSSA infections treatment indicates the necessity of antimicrobial stewardship improvement and introducing molecular screening for early identification of infections. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 13% |
| Researcher | 8 | 13% |
| Student > Doctoral Student | 6 | 10% |
| Other | 5 | 8% |
| Student > Master | 5 | 8% |
| Other | 11 | 18% |
| Unknown | 18 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 26% |
| Immunology and Microbiology | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Agricultural and Biological Sciences | 6 | 10% |
| Mathematics | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 20 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2015.
All research outputs
#15,088,428
of 24,396,012 outputs
Outputs from BMC Infectious Diseases
#3,880
of 8,159 outputs
Outputs of similar age
#140,040
of 269,029 outputs
Outputs of similar age from BMC Infectious Diseases
#62
of 142 outputs
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