| Title |
Interaction Between Brain Histamine and Serotonin, Norepinephrine, and Dopamine Systems: In Vivo Microdialysis and Electrophysiology Study
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, March 2015
|
| DOI | 10.1007/s12031-015-0536-3 |
| Pubmed ID | |
| Authors |
Gunnar Flik, Joost H. A. Folgering, Thomas I. H. F. Cremers, Ben H. C. Westerink, Eliyahu Dremencov |
| Abstract |
Brain monoamines (serotonin, norepinephrine, dopamine, and histamine) play an important role in emotions, cognition, and pathophysiology and treatment of mental disorders. The interactions between serotonin, norepinephrine, and dopamine were studied in numerous works; however, histamine system received less attention. The aim of this study was to investigate the interactions between histamine and other monoamines, using in vivo microdialysis and electrophysiology. It was found that the inverse agonist of histamine-3 receptors, thioperamide, increased the firing activity of dopamine neurons in the ventral tegmental area. Selective agonist of histamine-3 receptors, immepip, reversed thiperamide-induced stimulation of firing activity of dopamine neurons. The firing rates of serotonin and norpeinephrine neurons were not attenuated by immepip or thioperamide. Thioperamide robustly and significantly increased extracellular concentrations of serotonin, norepinephrine, and dopamine in the rat prefrontal cortex and slightly increased norepinephrine and dopamine levels in the tuberomammillary nucleus of the hypothalamus. It can be concluded that histamine stimulates serotonin, norepinephrine, and dopamine transmission in the brain. Modulation of firing of dopamine neurons is a key element in functional interactions between histamine and other monoamines. Antagonists of histamine-3 receptors, because of their potential ability to stimulate monoamine neurotransmission, might be beneficial in the treatment of mental disorders. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 11% |
| New Zealand | 1 | 11% |
| Australia | 1 | 11% |
| Pakistan | 1 | 11% |
| Slovakia | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Scientists | 1 | 11% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 3% |
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 75 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 8 | 10% |
| Student > Master | 6 | 8% |
| Student > Doctoral Student | 5 | 6% |
| Other | 19 | 24% |
| Unknown | 17 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 18% |
| Agricultural and Biological Sciences | 11 | 14% |
| Medicine and Dentistry | 8 | 10% |
| Chemistry | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 11 | 14% |
| Unknown | 26 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2024.
All research outputs
#4,685,143
of 25,374,647 outputs
Outputs from Journal of Molecular Neuroscience
#224
of 1,643 outputs
Outputs of similar age
#55,222
of 278,244 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#4
of 38 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,244 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.