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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
|
|---|---|
| Published in |
Genes & Development, April 2015
|
| DOI | 10.1101/gad.256958.114 |
| Pubmed ID | |
| Authors |
Andres J. Lopez-Contreras, Julia Specks, Jacqueline H. Barlow, Chiara Ambrogio, Claus Desler, Svante Vikingsson, Sara Rodrigo-Perez, Henrik Green, Lene Juel Rasmussen, Matilde Murga, André Nussenzweig, Oscar Fernandez-Capetillo |
| Abstract |
In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites. Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice. Our study reveals the first genetic condition in mammals that reduces fragile site expression and alleviates the severity of a progeroid disease by increasing RNR activity. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 33% |
| United Kingdom | 1 | 8% |
| Sweden | 1 | 8% |
| Ecuador | 1 | 8% |
| Unknown | 5 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 67% |
| Scientists | 4 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 122 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 27% |
| Student > Ph. D. Student | 25 | 20% |
| Student > Master | 12 | 10% |
| Professor > Associate Professor | 11 | 9% |
| Student > Bachelor | 7 | 6% |
| Other | 16 | 13% |
| Unknown | 20 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 42% |
| Agricultural and Biological Sciences | 40 | 32% |
| Medicine and Dentistry | 4 | 3% |
| Environmental Science | 1 | <1% |
| Arts and Humanities | 1 | <1% |
| Other | 4 | 3% |
| Unknown | 22 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2015.
All research outputs
#1,157,421
of 22,797,621 outputs
Outputs from Genes & Development
#271
of 5,835 outputs
Outputs of similar age
#16,107
of 263,845 outputs
Outputs of similar age from Genes & Development
#3
of 57 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,835 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,845 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.