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Mendeley readers
Attention Score in Context
| Title |
Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy
|
|---|---|
| Published in |
PLoS Genetics, February 2010
|
| DOI | 10.1371/journal.pgen.1000856 |
| Pubmed ID | |
| Authors |
Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Kirsi Sipilä, Raija Lähdesmäki, Iona Y. Millwood, Marika Kaakinen, Gopalakrishnan Netuveli, David Blane, Pimphen Charoen, Ulla Sovio, Anneli Pouta, Nelson Freimer, Anna-Liisa Hartikainen, Jaana Laitinen, Sarianna Vaara, Beate Glaser, Peter Crawford, Nicholas J. Timpson, Susan M. Ring, Guohong Deng, Weihua Zhang, Mark I. McCarthy, Panos Deloukas, Leena Peltonen, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin |
| Abstract |
Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5x10(-8), and 5 with suggestive association (P<5x10(-6)). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| Latvia | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 136 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 42 | 29% |
| Student > Ph. D. Student | 27 | 19% |
| Professor | 12 | 8% |
| Student > Master | 10 | 7% |
| Student > Postgraduate | 8 | 6% |
| Other | 28 | 20% |
| Unknown | 16 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 47 | 33% |
| Agricultural and Biological Sciences | 35 | 24% |
| Biochemistry, Genetics and Molecular Biology | 18 | 13% |
| Computer Science | 5 | 3% |
| Social Sciences | 5 | 3% |
| Other | 12 | 8% |
| Unknown | 21 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2011.
All research outputs
#2,194,867
of 25,411,814 outputs
Outputs from PLoS Genetics
#1,799
of 8,964 outputs
Outputs of similar age
#7,913
of 102,481 outputs
Outputs of similar age from PLoS Genetics
#13
of 63 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,964 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,481 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.