Title |
Behavioral Intervention Improves Treatment Outcomes Among HIV-Infected Individuals Who Have Delayed, Declined, or Discontinued Antiretroviral Therapy: A Randomized Controlled Trial of a Novel Intervention
|
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Published in |
AIDS and Behavior, April 2015
|
DOI | 10.1007/s10461-015-1054-6 |
Pubmed ID | |
Authors |
Marya Gwadz, Charles M. Cleland, Elizabeth Applegate, Mindy Belkin, Monica Gandhi, Nadim Salomon, Angela Banfield, Noelle Leonard, Marion Riedel, Hannah Wolfe, Isaiah Pickens, Kelly Bolger, DeShannon Bowens, David Perlman, Donna Mildvan, The Heart to Heart Collaborative Research Team |
Abstract |
Nationally up to 60 % of persons living with HIV are neither taking antiretroviral therapy (ART) nor well engaged in HIV care, mainly racial/ethnic minorities. This study examined a new culturally targeted multi-component intervention to address emotional, attitudinal, and social/structural barriers to ART initiation and HIV care. Participants (N = 95) were African American/Black and Latino adults with CD4 < 500 cells/mm(3) not taking ART, randomized 1:1 to intervention or control arms, the latter receiving treatment as usual. Primary endpoints were adherence, evaluated via ART concentrations in hair samples, and HIV viral load suppression. The intervention was feasible and acceptable. Eight months post-baseline, intervention participants tended to be more likely to evidence "good" (that is, 7 days/week) adherence (60 vs. 26.7 %; p = 0.087; OR = 3.95), and had lower viral load levels than controls (t(22) = 2.29, p = 0.032; OR = 5.20), both large effect sizes. This highly promising intervention merits further study. |
Mendeley readers
Geographical breakdown
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Italy | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 140 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 19 | 13% |
Student > Ph. D. Student | 17 | 12% |
Student > Bachelor | 15 | 11% |
Student > Doctoral Student | 10 | 7% |
Other | 26 | 18% |
Unknown | 35 | 25% |
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Social Sciences | 16 | 11% |
Nursing and Health Professions | 15 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 14 | 10% |
Unknown | 40 | 28% |