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Scabies Mite Peritrophins Are Potential Targets of Human Host Innate Immunity

Overview of attention for article published in PLoS Neglected Tropical Diseases, September 2011
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Title
Scabies Mite Peritrophins Are Potential Targets of Human Host Innate Immunity
Published in
PLoS Neglected Tropical Diseases, September 2011
DOI 10.1371/journal.pntd.0001331
Pubmed ID
Authors

Angela Mika, Priscilla Goh, Deborah C. Holt, Dave J. Kemp, Katja Fischer

Abstract

Pruritic scabies lesions caused by Sarcoptes scabiei burrowing in the stratum corneum of human skin facilitate opportunistic bacterial infections. Emerging resistance to current therapeutics emphasizes the need to identify novel targets for protective intervention. We have characterized several protein families located in the mite gut as crucial factors for host-parasite interactions. Among these multiple proteins inhibit human complement, presumably to avoid complement-mediated damage of gut epithelial cells. Peritrophins are major components of the peritrophic matrix often found in the gut of arthropods. We hypothesized that a peritrophin, if abundant in the scabies mite gut, could be an activator of complement.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 22%
Student > Ph. D. Student 4 11%
Other 3 8%
Student > Postgraduate 3 8%
Student > Master 3 8%
Other 5 14%
Unknown 10 28%
Readers by discipline Count As %
Medicine and Dentistry 11 31%
Agricultural and Biological Sciences 8 22%
Immunology and Microbiology 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Environmental Science 1 3%
Other 2 6%
Unknown 10 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2011.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from PLoS Neglected Tropical Diseases
#7,312
of 9,377 outputs
Outputs of similar age
#100,456
of 142,688 outputs
Outputs of similar age from PLoS Neglected Tropical Diseases
#61
of 81 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,377 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,688 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.