↓ Skip to main content

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators

Overview of attention for article published in Synthesis, March 2015
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
22 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators
Published in
Synthesis, March 2015
DOI 10.1055/s-0034-1380114
Pubmed ID
Authors

Mark W Irvine, Guangyu Fang, Richard Eaves, Maria B Mayo-Martin, Erica S Burnell, Blaise M Costa, Georgia R Culley, Arturas Volianskis, Graham L Collingridge, Daniel T Monaghan, David E Jane

Abstract

9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the NMDA receptor. This receptor is activated by the excitatory neurotransmitter L-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain and neurodegenerative disorders such as Alzheimer's disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 9%
Student > Master 2 9%
Researcher 2 9%
Student > Ph. D. Student 2 9%
Other 1 5%
Other 3 14%
Unknown 10 45%
Readers by discipline Count As %
Chemistry 5 23%
Unspecified 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Immunology and Microbiology 1 5%
Nursing and Health Professions 1 5%
Other 2 9%
Unknown 11 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2015.
All research outputs
#20,267,098
of 22,797,621 outputs
Outputs from Synthesis
#4,526
of 4,617 outputs
Outputs of similar age
#223,274
of 263,729 outputs
Outputs of similar age from Synthesis
#12
of 17 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,617 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,729 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.