Title |
Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators
|
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Published in |
Synthesis, March 2015
|
DOI | 10.1055/s-0034-1380114 |
Pubmed ID | |
Authors |
Mark W Irvine, Guangyu Fang, Richard Eaves, Maria B Mayo-Martin, Erica S Burnell, Blaise M Costa, Georgia R Culley, Arturas Volianskis, Graham L Collingridge, Daniel T Monaghan, David E Jane |
Abstract |
9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the NMDA receptor. This receptor is activated by the excitatory neurotransmitter L-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain and neurodegenerative disorders such as Alzheimer's disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor. |
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