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Macro- and micro-structural white matter differences correlate with cognitive performance in healthy aging

Overview of attention for article published in Brain Imaging and Behavior, April 2015
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Title
Macro- and micro-structural white matter differences correlate with cognitive performance in healthy aging
Published in
Brain Imaging and Behavior, April 2015
DOI 10.1007/s11682-015-9378-4
Pubmed ID
Authors

Paulo César Gonçalves Marques, José Miguel Montenegro Soares, Ricardo José da Silva Magalhães, Nadine Correia Santos, Nuno Jorge Carvalho Sousa

Abstract

Studies have shown that white matter (WM) volumetric reductions and overall degradation occur with aging. Nonetheless little is known about the WM alterations that may underlie different cognitive status in older individuals. The main goal of the present work was to identify and characterize possible macro and microstructural WM alterations that could distinguish between older healthy individuals with contrasting cognitive profiles (i.e., "poor" vs "good" cognitive performers). Structural and diffusion magnetic resonance imaging was performed in order to quantify local WM volumes, white matter signal abnormalities (WMSA) volume (a measure of lesion burden) and diffusion tensor imaging scalar maps known to probe WM microstructure. A battery of neurocognitive/psychological tests was administered to assess the cognitive performance. Poor performers showed a higher slope for the positive association between WMSA volume and age compared to good performers. Even when controlling for WMSA volume, poor performers also evidenced lower fractional anisotropy, as well as positive associations with age with higher slopes of regression parameters in radial and axial diffusivity. Altogether results suggest that cognitive performance is related to differences in WM, with poor cognitive performers displaying signs of faster aging in WM.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Ph. D. Student 6 15%
Student > Master 6 15%
Student > Doctoral Student 4 10%
Other 3 8%
Other 5 13%
Unknown 9 23%
Readers by discipline Count As %
Psychology 8 20%
Medicine and Dentistry 6 15%
Neuroscience 5 13%
Computer Science 2 5%
Mathematics 1 3%
Other 7 18%
Unknown 11 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2019.
All research outputs
#13,939,342
of 22,797,621 outputs
Outputs from Brain Imaging and Behavior
#537
of 1,155 outputs
Outputs of similar age
#135,020
of 264,674 outputs
Outputs of similar age from Brain Imaging and Behavior
#19
of 35 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,674 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.