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Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, March 2015
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Title
Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis
Published in
Antimicrobial Agents and Chemotherapy, March 2015
DOI 10.1128/aac.00171-15
Pubmed ID
Authors

L. Davies Forsman, C. G. Giske, J. Bruchfeld, T. Schön, P. Juréen, K. Ängeby

Abstract

We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 M. tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis isolates (MDR/XDR-TB), since the activity of MEM-CLA for resistant isolates has not been studied extensively previously. Using Middlebrook 7H10 medium, all but four isolates showed a MIC distribution of 0.125-2 mg/L of MEM-CLA, below the non-species related breakpoint for MEM of 2 mg/L defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 14%
Researcher 5 12%
Student > Bachelor 5 12%
Student > Ph. D. Student 5 12%
Student > Postgraduate 3 7%
Other 7 16%
Unknown 12 28%
Readers by discipline Count As %
Medicine and Dentistry 11 26%
Biochemistry, Genetics and Molecular Biology 7 16%
Agricultural and Biological Sciences 4 9%
Immunology and Microbiology 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 9%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2016.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#13,973
of 15,579 outputs
Outputs of similar age
#206,937
of 278,145 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#156
of 218 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 15,579 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,145 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 218 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.