| Title |
Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, September 2013
|
| DOI | 10.1007/s00259-013-2525-5 |
| Pubmed ID | |
| Authors |
Ali Afshar-Oromieh, Christian M. Zechmann, Anna Malcher, Matthias Eder, Michael Eisenhut, Heinz G. Linhart, Tim Holland-Letz, Boris A. Hadaschik, Frederik L. Giesel, Jürgen Debus, Uwe Haberkorn |
| Abstract |
Positron emission tomography (PET) with choline tracers has found widespread use for the diagnosis of prostate cancer (PC). However, choline metabolism is not increased in a considerable number of cases, whereas prostate-specific membrane antigen (PSMA) is overexpressed in most PCs. Therefore, a (68)Ga-labelled PSMA ligand could be superior to choline tracers by obtaining a high contrast. The aim of this study was to compare such a novel tracer with standard choline-based PET/CT. Thirty-seven patients with biochemical relapse of PC [mean prostate-specific antigen (PSA) 11.1 ± 24.1 ng/ml, range 0.01-116] were retrospectively analysed after (18)F-fluoromethylcholine and (68)Ga-PSMA PET/CT within a time window of 30 days. Radiotracer uptake that was visually considered as PC was semi-quantitatively analysed by measuring the maximum standardized uptake values (SUVmax) of the scans acquired 1 h after injection of (68)Ga-PSMA complex solution (median 132 MBq, range 59-263 MBq) and (18)F-fluoromethylcholine (median 237 MBq, range 114-374 MBq), respectively. In addition, tumour to background ratios were calculated. A total of 78 lesions characteristic for PC were detected in 32 patients using (68)Ga-PSMA PET/CT and 56 lesions were detected in 26 patients using choline PET/CT. The higher detection rate in (68)Ga-PSMA PET/CT was statistically significant (p=0.04). In five patients no lesion was found with both methods. All lesions detected by (18)F-fluoromethylcholine PET/CT were also seen by (68)Ga-PSMA PET/CT. In (68)Ga-PSMA PET/CT SUVmax was clearly (>10 %) higher in 62 of 78 lesions (79.1 %) and the tumour to background ratio was clearly (>10 %) higher in 74 of 78 lesions (94.9 %) when compared to (18)F-fluoromethylcholine PET/CT. (68)Ga-PSMA PET/CT can detect lesions characteristic for PC with improved contrast when compared to standard (18)F-fluoromethylcholine PET/CT, especially at low PSA levels. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 459 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | <1% |
| Germany | 2 | <1% |
| Sweden | 2 | <1% |
| Netherlands | 1 | <1% |
| Switzerland | 1 | <1% |
| India | 1 | <1% |
| Canada | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 446 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 75 | 16% |
| Student > Ph. D. Student | 59 | 13% |
| Student > Master | 46 | 10% |
| Other | 45 | 10% |
| Student > Bachelor | 41 | 9% |
| Other | 103 | 22% |
| Unknown | 90 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 201 | 44% |
| Chemistry | 37 | 8% |
| Engineering | 18 | 4% |
| Physics and Astronomy | 17 | 4% |
| Biochemistry, Genetics and Molecular Biology | 15 | 3% |
| Other | 59 | 13% |
| Unknown | 112 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#2,548,745
of 26,017,215 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#181
of 3,565 outputs
Outputs of similar age
#22,152
of 219,695 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#2
of 36 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,565 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,695 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.