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Cavin family proteins and the assembly of caveolae

Overview of attention for article published in Journal of Cell Science, March 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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1 X user
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1 Facebook page
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4 Wikipedia pages

Citations

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177 Dimensions

Readers on

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182 Mendeley
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1 CiteULike
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Title
Cavin family proteins and the assembly of caveolae
Published in
Journal of Cell Science, March 2015
DOI 10.1242/jcs.167866
Pubmed ID
Authors

Oleksiy Kovtun, Vikas A. Tillu, Nicholas Ariotti, Robert G. Parton, Brett M. Collins

Abstract

Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as essential coat components and regulators of caveola biogenesis. In this Commentary, we summarise recent data on the role of cavins in caveola formation, highlighting structural studies that provide new insights into cavin coat assembly. In mammals, there are four cavin family members that associate through homo- and hetero-oligomerisation to form distinct subcomplexes on caveolae, which can be released into the cell in response to stimuli. Studies from several labs have provided a better understanding of cavin stoichiometry and the molecular basis for their oligomerisation, as well as identifying interactions with membrane phospholipids that may be important for caveola function. We propose a model in which coincident, low-affinity electrostatically controlled protein-protein and protein-lipid interactions allow the formation of caveolae, generating a meta-stable structure that can respond to plasma membrane stress by release of cavins.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 178 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 25%
Researcher 24 13%
Student > Bachelor 23 13%
Student > Master 16 9%
Other 11 6%
Other 29 16%
Unknown 33 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 64 35%
Agricultural and Biological Sciences 39 21%
Medicine and Dentistry 11 6%
Chemistry 6 3%
Engineering 6 3%
Other 18 10%
Unknown 38 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2021.
All research outputs
#7,778,071
of 25,373,627 outputs
Outputs from Journal of Cell Science
#3,240
of 9,019 outputs
Outputs of similar age
#86,015
of 279,249 outputs
Outputs of similar age from Journal of Cell Science
#16
of 46 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 9,019 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.