You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
PIT and alcohol relapse
|
|---|---|
| Published in |
Addiction Biology, April 2015
|
| DOI | 10.1111/adb.12243 |
| Pubmed ID | |
| Authors |
Maria Garbusow, Daniel J Schad, Miriam Sebold, Eva Friedel, Nadine Bernhardt, Stefan P Koch, Bruno Steinacher, Norbert Kathmann, Dirk E M Geurts, Christian Sommer, Dirk K Müller, Stephan Nebe, Sören Paul, Hans-Ulrich Wittchen, Ulrich S Zimmermann, Henrik Walter, Michael N Smolka, Philipp Sterzer, Michael A Rapp, Quentin J M Huys, Florian Schlagenhauf, Andreas Heinz |
| Abstract |
In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n = 31 detoxified patients diagnosed with alcohol dependence and n = 24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 179 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 21% |
| Researcher | 33 | 18% |
| Student > Master | 24 | 13% |
| Student > Bachelor | 18 | 10% |
| Student > Postgraduate | 11 | 6% |
| Other | 24 | 13% |
| Unknown | 33 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 70 | 39% |
| Neuroscience | 34 | 19% |
| Medicine and Dentistry | 16 | 9% |
| Agricultural and Biological Sciences | 7 | 4% |
| Computer Science | 3 | 2% |
| Other | 9 | 5% |
| Unknown | 42 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2017.
All research outputs
#14,914,476
of 25,373,627 outputs
Outputs from Addiction Biology
#714
of 1,171 outputs
Outputs of similar age
#136,269
of 279,166 outputs
Outputs of similar age from Addiction Biology
#8
of 25 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,171 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.