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Posttraumatic and depressive symptoms in β-endorphin dynamics

Overview of attention for article published in Journal of Affective Disorders, April 2015
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Title
Posttraumatic and depressive symptoms in β-endorphin dynamics
Published in
Journal of Affective Disorders, April 2015
DOI 10.1016/j.jad.2015.03.063
Pubmed ID
Authors

Danka Savic, Goran Knezevic, Gordana Matic, Svetozar Damjanovic, Zeljko Spiric

Abstract

A disturbed beta-endorphin system can be a part of the post-traumatic stress disorder (PTSD) and depression allostasis. Study subjects (N=392) included those with PTSD and/or (stress-induced) depression, and healthy controls with and without traumas. The aim of the study was to examine the network of relations centered around plasma beta-endorphin. The network included anxiety (as a personality trait), traumatic events, pain, aggressiveness, depressive symptoms, and three clusters of PTSD symptoms: intrusions, avoidance, and hyperarousal. Beta-endorphin was represented by individual mean from 13 time points (BEmean), reflecting the total amount of the peripherally secreted hormone, and the coefficient of variation (BEvar), calculated as the ratio of standard deviation to the mean, reflecting the hormone׳s dynamics. BEvar correlated with all other variables, BEmean had no correlations. Structural equation modeling (SEM) was used to examine all interrelations (including their directions) of BEvar and the state/trait variables in the context of their entirety. The model revealed that hyperarousal and anxiety were the only direct agents of peripheral beta-endorphin fluctuations, mediating the effects of other variables. Traumatic events and intrusions act on BEvar via hyperarousal, while depressive symptoms, avoidance, and pain act via anxiety. Hyperarousal should be emphasized as the main agent not only because its effect on BEvar is larger than that of anxiety, but also because it increases anxiety itself (via avoidance and pain). All influences on BEvar are positive and they indicate long-term (sensitizing) effects (as opposed to direct stimulation, for example, by acute pain, anger, etc.). Relations apart from beta-endorphin are also discussed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Serbia 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 15%
Student > Bachelor 10 15%
Student > Ph. D. Student 8 12%
Researcher 7 10%
Other 5 7%
Other 21 31%
Unknown 6 9%
Readers by discipline Count As %
Psychology 18 27%
Medicine and Dentistry 11 16%
Social Sciences 6 9%
Neuroscience 5 7%
Unspecified 4 6%
Other 12 18%
Unknown 11 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Journal of Affective Disorders
#9,042
of 10,146 outputs
Outputs of similar age
#241,103
of 279,944 outputs
Outputs of similar age from Journal of Affective Disorders
#142
of 179 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 179 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.