↓ Skip to main content

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2015
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
7 news outlets
blogs
2 blogs
twitter
8 X users
patent
7 patents
facebook
1 Facebook page
wikipedia
5 Wikipedia pages
googleplus
1 Google+ user
f1000
1 research highlight platform

Citations

dimensions_citation
351 Dimensions

Readers on

mendeley
224 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication
Published in
Proceedings of the National Academy of Sciences of the United States of America, April 2015
DOI 10.1073/pnas.1421178112
Pubmed ID
Authors

Yury A. Bochkov, Kelly Watters, Shamaila Ashraf, Theodor F. Griggs, Mark K. Devries, Daniel J. Jackson, Ann C. Palmenberg, James E. Gern

Abstract

Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and asthma exacerbations compared with other rhinoviruses. The cellular receptor for these viruses was heretofore unknown. We report here that expression of human cadherin-related family member 3 (CDHR3) enables the cells normally unsusceptible to RV-C infection to support both virus binding and replication. A coding single nucleotide polymorphism (rs6967330, C529Y) was previously linked to greater cell-surface expression of CDHR3 protein, and an increased risk of wheezing illnesses and hospitalizations for childhood asthma. Compared with wild-type CDHR3, cells transfected with the CDHR3-Y529 variant had about 10-fold increases in RV-C binding and progeny yields. We developed a transduced HeLa cell line (HeLa-E8) stably expressing CDHR3-Y529 that supports RV-C propagation in vitro. Modeling of CDHR3 structure identified potential binding sites that could impact the virus surface in regions that are highly conserved among all RV-C types. Our findings identify that the asthma susceptibility gene product CDHR3 mediates RV-C entry into host cells, and suggest that rs6967330 mutation could be a risk factor for RV-C wheezing illnesses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Australia 1 <1%
Unknown 220 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 24%
Researcher 34 15%
Student > Bachelor 30 13%
Student > Master 23 10%
Student > Doctoral Student 14 6%
Other 30 13%
Unknown 39 17%
Readers by discipline Count As %
Medicine and Dentistry 51 23%
Biochemistry, Genetics and Molecular Biology 46 21%
Agricultural and Biological Sciences 42 19%
Immunology and Microbiology 23 10%
Engineering 4 2%
Other 14 6%
Unknown 44 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#519,660
of 24,942,536 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#9,151
of 102,035 outputs
Outputs of similar age
#6,147
of 270,095 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#149
of 971 outputs
Altmetric has tracked 24,942,536 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 102,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.9. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,095 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 971 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.