Chapter title |
Plasticity of inhibition in the spinal cord.
|
---|---|
Chapter number | 9 |
Book title |
Pain Control
|
Published in |
Handbook of experimental pharmacology, January 2015
|
DOI | 10.1007/978-3-662-46450-2_9 |
Pubmed ID | |
Book ISBNs |
978-3-66-246449-6, 978-3-66-246450-2
|
Authors |
Todd, Andrew J, Andrew J. Todd, Todd, Andrew J. |
Abstract |
Inhibitory interneurons, which use GABA and/or glycine as their principal transmitter, have numerous roles in regulating the transmission of sensory information through the spinal dorsal horn. These roles are likely to be performed by different populations of interneurons, each with specific locations in the synaptic circuitry of the region. Peripheral nerve injury frequently leads to neuropathic pain, and it is thought that loss of function of inhibitory interneurons in the dorsal horn contributes to this condition. Several mechanisms have been proposed for this disinhibition, including death of inhibitory interneurons, decreased transmitter release, diminished activity of these cells and reduced effectiveness of GABA and glycine as inhibitory transmitters. However, despite numerous studies on this important topic, it is still not clear which (if any) of these mechanisms contributes to neuropathic pain after nerve injury. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 2% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 21% |
Student > Master | 9 | 21% |
Researcher | 5 | 12% |
Student > Postgraduate | 3 | 7% |
Professor | 2 | 5% |
Other | 9 | 21% |
Unknown | 5 | 12% |
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Other | 2 | 5% |
Unknown | 8 | 19% |