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X Demographics
Mendeley readers
Attention Score in Context
| Title |
High-throughput functional genomics using CRISPR–Cas9
|
|---|---|
| Published in |
Nature Reviews Genetics, April 2015
|
| DOI | 10.1038/nrg3899 |
| Pubmed ID | |
| Authors |
Ophir Shalem, Neville E. Sanjana, Feng Zhang |
| Abstract |
Forward genetic screens are powerful tools for the discovery and functional annotation of genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease has been combined with genome-scale guide RNA libraries for unbiased, phenotypic screening. In this Review, we describe recent advances using Cas9 for genome-scale screens, including knockout approaches that inactivate genomic loci and strategies that modulate transcriptional activity. We discuss practical aspects of screen design, provide comparisons with RNA interference (RNAi) screening, and outline future applications and challenges. |
X Demographics
The data shown below were collected from the profiles of 66 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 27% |
| United Kingdom | 11 | 17% |
| Germany | 3 | 5% |
| France | 2 | 3% |
| New Zealand | 1 | 2% |
| Italy | 1 | 2% |
| Oman | 1 | 2% |
| Spain | 1 | 2% |
| Brazil | 1 | 2% |
| Other | 10 | 15% |
| Unknown | 17 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 32 | 48% |
| Members of the public | 30 | 45% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 2,943 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | <1% |
| Germany | 12 | <1% |
| United Kingdom | 10 | <1% |
| Canada | 5 | <1% |
| Japan | 4 | <1% |
| Denmark | 4 | <1% |
| Austria | 4 | <1% |
| Brazil | 4 | <1% |
| Italy | 4 | <1% |
| Other | 36 | 1% |
| Unknown | 2838 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 691 | 23% |
| Researcher | 628 | 21% |
| Student > Bachelor | 370 | 13% |
| Student > Master | 318 | 11% |
| Student > Doctoral Student | 131 | 4% |
| Other | 414 | 14% |
| Unknown | 391 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1051 | 36% |
| Biochemistry, Genetics and Molecular Biology | 897 | 30% |
| Medicine and Dentistry | 160 | 5% |
| Immunology and Microbiology | 85 | 3% |
| Neuroscience | 69 | 2% |
| Other | 234 | 8% |
| Unknown | 447 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 73. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#593,624
of 25,837,817 outputs
Outputs from Nature Reviews Genetics
#316
of 2,745 outputs
Outputs of similar age
#6,986
of 281,916 outputs
Outputs of similar age from Nature Reviews Genetics
#7
of 39 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,745 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,916 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.