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Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

Overview of attention for article published in Nature Biomedical Engineering, April 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
11 news outlets
blogs
3 blogs
twitter
71 X users
facebook
4 Facebook pages

Citations

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258 Dimensions

Readers on

mendeley
315 Mendeley
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Title
Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells
Published in
Nature Biomedical Engineering, April 2018
DOI 10.1038/s41551-018-0229-7
Pubmed ID
Authors

Bohao Liu, Benjamin W. Lee, Koki Nakanishi, Aranzazu Villasante, Rebecca Williamson, Jordan Metz, Jinho Kim, Mariko Kanai, Lynn Bi, Kristy Brown, Gilbert Di Paolo, Shunichi Homma, Peter A. Sims, Veli K. Topkara, Gordana Vunjak-Novakovic

Abstract

The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been exploited for the treatment of diseases. For example, EVs secreted by stem cells injected into infarcted hearts can induce recovery through the delivery of stem-cell-specific miRNAs. However, the retention of the EVs and the therapeutic effects are short-lived. Here, we show that an engineered hydrogel patch capable of slowly releasing EVs secreted from cardiomyocytes derived from induced pluripotent stem (iPS) cells reduced arrhythmic burden, promoted ejection-fraction recovery, decreased cardiomyocyte apoptosis 24 hours after infarction, and reduced infarct size and cell hypertrophy 4 weeks post-infarction when implanted onto infarcted rat hearts. We also show that the EVs are enriched with cardiac-specific miRNAs known to modulate cardiomyocyte-specific processes. The extended delivery of EVs secreted from iPS-cell-derived cardiomyocytes into the heart may help understand heart recovery and treat heart injury.

X Demographics

X Demographics

The data shown below were collected from the profiles of 71 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 315 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 315 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 65 21%
Researcher 42 13%
Student > Master 37 12%
Student > Bachelor 33 10%
Student > Doctoral Student 18 6%
Other 36 11%
Unknown 84 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 57 18%
Medicine and Dentistry 39 12%
Engineering 38 12%
Materials Science 18 6%
Agricultural and Biological Sciences 17 5%
Other 43 14%
Unknown 103 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 133. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2019.
All research outputs
#307,599
of 25,204,906 outputs
Outputs from Nature Biomedical Engineering
#194
of 1,125 outputs
Outputs of similar age
#6,993
of 332,745 outputs
Outputs of similar age from Nature Biomedical Engineering
#6
of 31 outputs
Altmetric has tracked 25,204,906 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,125 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 87.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.