Title |
Building endocytic pits without clathrin
|
---|---|
Published in |
Nature Reviews Molecular Cell Biology, April 2015
|
DOI | 10.1038/nrm3968 |
Pubmed ID | |
Authors |
Ludger Johannes, Robert G. Parton, Patricia Bassereau, Satyajit Mayor |
Abstract |
How endocytic pits are built in clathrin- and caveolin-independent endocytosis still remains poorly understood. Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules. We discuss the need for different types of internalization processes in the context of diverse cellular functions, the existence of clathrin-independent mechanisms of cargo recruitment and membrane bending from a biological and physical perspective, and finally propose a generic scheme for the formation of clathrin-independent endocytic pits. |
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Geographical breakdown
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Brazil | 1 | 33% |
United Kingdom | 1 | 33% |
Ecuador | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 4 | 1% |
United Kingdom | 4 | 1% |
Germany | 2 | <1% |
France | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 348 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 98 | 27% |
Researcher | 75 | 21% |
Student > Master | 42 | 12% |
Student > Bachelor | 24 | 7% |
Student > Doctoral Student | 22 | 6% |
Other | 55 | 15% |
Unknown | 44 | 12% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 100 | 28% |
Chemistry | 18 | 5% |
Physics and Astronomy | 15 | 4% |
Engineering | 12 | 3% |
Other | 45 | 13% |
Unknown | 49 | 14% |