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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A coding-independent function of an alternative Ube3a transcript during neuronal development
|
|---|---|
| Published in |
Nature Neuroscience, April 2015
|
| DOI | 10.1038/nn.3996 |
| Pubmed ID | |
| Authors |
Jeremy Valluy, Silvia Bicker, Ayla Aksoy-Aksel, Martin Lackinger, Simon Sumer, Roberto Fiore, Tatjana Wüst, Dominik Seffer, Franziska Metge, Christoph Dieterich, Markus Wöhr, Rainer Schwarting, Gerhard Schratt |
| Abstract |
The E3 ubiquitin ligase Ube3a is an important regulator of activity-dependent synapse development and plasticity. Ube3a mutations cause Angelman syndrome and have been associated with autism spectrum disorders (ASD). However, the biological significance of alternative Ube3a transcripts generated in mammalian neurons remains unknown. We report here that Ube3a1 RNA, a transcript that encodes a truncated Ube3a protein lacking catalytic activity, prevents exuberant dendrite growth and promotes spine maturation in rat hippocampal neurons. Surprisingly, Ube3a1 RNA function was independent of its coding sequence but instead required a unique 3' untranslated region and an intact microRNA pathway. Ube3a1 RNA knockdown increased activity of the plasticity-regulating miR-134, suggesting that Ube3a1 RNA acts as a dendritic competing endogenous RNA. Accordingly, the dendrite-growth-promoting effect of Ube3a1 RNA knockdown in vivo is abolished in mice lacking miR-134. Taken together, our results define a noncoding function of an alternative Ube3a transcript in dendritic protein synthesis, with potential implications for Angelman syndrome and ASD. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 14% |
| Germany | 1 | 14% |
| United States | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 179 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 27% |
| Researcher | 48 | 26% |
| Student > Bachelor | 14 | 7% |
| Student > Master | 13 | 7% |
| Student > Doctoral Student | 10 | 5% |
| Other | 24 | 13% |
| Unknown | 27 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 27% |
| Biochemistry, Genetics and Molecular Biology | 38 | 20% |
| Neuroscience | 36 | 19% |
| Medicine and Dentistry | 14 | 7% |
| Psychology | 7 | 4% |
| Other | 12 | 6% |
| Unknown | 30 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#961,442
of 25,756,531 outputs
Outputs from Nature Neuroscience
#1,590
of 5,660 outputs
Outputs of similar age
#11,656
of 280,028 outputs
Outputs of similar age from Nature Neuroscience
#31
of 73 outputs
Altmetric has tracked 25,756,531 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,660 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 58.1. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,028 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.