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Biomonitoring Equivalents for interpretation of urinary fluoride

Overview of attention for article published in Regulatory Toxicology & Pharmacology: RTP, April 2015
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Title
Biomonitoring Equivalents for interpretation of urinary fluoride
Published in
Regulatory Toxicology & Pharmacology: RTP, April 2015
DOI 10.1016/j.yrtph.2015.04.005
Pubmed ID
Authors

L.L. Aylward, S.M. Hays, A. Vezina, M. Deveau, A. St-Amand, A. Nong

Abstract

Exposure to fluoride is widespread due to its natural occurrence in the environment and addition to drinking water and dental products for the prevention of dental caries. The potential health risks of excess fluoride exposure include aesthetically unacceptable dental fluorosis (tooth mottling) and increased skeletal fragility. Numerous organizations have conducted risk assessments and set guidance values to represent maximum recommended exposure levels as well as recommended adequate intake levels based on potential public health benefits of fluoride exposure. Biomonitoring Equivalents (BEs) are estimates of the average biomarker concentrations corresponding to such exposure guidance values. The literature on daily urinary fluoride excretion rates as a function of daily fluoride exposure was reviewed and BE values corresponding to the available US and Canadian exposure guidance values were derived for fluoride in urine. The derived BE values range from 1.1 to 2.1 mg/L (1.2-2.5 μg/g creatinine). Concentrations of fluoride in single urinary spot samples from individuals, even under exposure conditions consistent with the exposure guidance values, may vary from the predicted average concentrations by several-fold due to within- and across- individual variation in urinary flow and creatinine excretion rates and due to the rapid elimination kinetics of fluoride. Thus, the BE values are most appropriately applied to screen population central tendency estimates for biomarker concentrations rather than interpretation of individual spot sample concentrations.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 4%
Poland 1 2%
Unknown 47 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 22%
Student > Master 10 20%
Student > Ph. D. Student 5 10%
Student > Doctoral Student 2 4%
Other 2 4%
Other 4 8%
Unknown 16 32%
Readers by discipline Count As %
Medicine and Dentistry 11 22%
Environmental Science 4 8%
Psychology 3 6%
Agricultural and Biological Sciences 2 4%
Nursing and Health Professions 2 4%
Other 8 16%
Unknown 20 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2015.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Regulatory Toxicology & Pharmacology: RTP
#1,720
of 2,141 outputs
Outputs of similar age
#170,445
of 279,935 outputs
Outputs of similar age from Regulatory Toxicology & Pharmacology: RTP
#24
of 37 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,141 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,935 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.