Title |
Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak
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Published in |
Virology, April 2015
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DOI | 10.1016/j.virol.2015.03.029 |
Pubmed ID | |
Authors |
Abayomi S. Olabode, Xiaowei Jiang, David L. Robertson, Simon C. Lovell |
Abstract |
The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to humans, accounting for the scale of the 2014 outbreak. We computationally analyze the variation associated with all EVD outbreaks, and find none of the amino acid replacements lead to identifiable functional changes. These changes have minimal effect on protein structure, being neither stabilizing nor destabilizing, are not found in regions of the proteins associated with known functions and tend to cluster in poorly constrained regions of proteins, specifically intrinsically disordered regions. We find no evidence that the difference between the current and previous outbreaks is due to evolutionary changes associated with transmission to humans. Instead, epidemiological factors are likely to be responsible for the unprecedented spread of EVD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 5 | 50% |
India | 1 | 10% |
Australia | 1 | 10% |
United States | 1 | 10% |
Unknown | 2 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 70% |
Scientists | 3 | 30% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
Canada | 2 | 2% |
Mexico | 1 | 1% |
Japan | 1 | 1% |
Unknown | 87 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 23% |
Student > Bachelor | 19 | 20% |
Researcher | 17 | 18% |
Student > Master | 10 | 11% |
Other | 8 | 9% |
Other | 12 | 13% |
Unknown | 6 | 6% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 31 | 33% |
Medicine and Dentistry | 19 | 20% |
Biochemistry, Genetics and Molecular Biology | 17 | 18% |
Immunology and Microbiology | 5 | 5% |
Nursing and Health Professions | 3 | 3% |
Other | 10 | 11% |
Unknown | 8 | 9% |