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Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak

Overview of attention for article published in Virology, April 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
4 news outlets
blogs
3 blogs
policy
1 policy source
twitter
10 X users

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
93 Mendeley
citeulike
1 CiteULike
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Title
Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak
Published in
Virology, April 2015
DOI 10.1016/j.virol.2015.03.029
Pubmed ID
Authors

Abayomi S. Olabode, Xiaowei Jiang, David L. Robertson, Simon C. Lovell

Abstract

The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to humans, accounting for the scale of the 2014 outbreak. We computationally analyze the variation associated with all EVD outbreaks, and find none of the amino acid replacements lead to identifiable functional changes. These changes have minimal effect on protein structure, being neither stabilizing nor destabilizing, are not found in regions of the proteins associated with known functions and tend to cluster in poorly constrained regions of proteins, specifically intrinsically disordered regions. We find no evidence that the difference between the current and previous outbreaks is due to evolutionary changes associated with transmission to humans. Instead, epidemiological factors are likely to be responsible for the unprecedented spread of EVD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Canada 2 2%
Mexico 1 1%
Japan 1 1%
Unknown 87 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 23%
Student > Bachelor 19 20%
Researcher 17 18%
Student > Master 10 11%
Other 8 9%
Other 12 13%
Unknown 6 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 33%
Medicine and Dentistry 19 20%
Biochemistry, Genetics and Molecular Biology 17 18%
Immunology and Microbiology 5 5%
Nursing and Health Professions 3 3%
Other 10 11%
Unknown 8 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2018.
All research outputs
#639,253
of 25,394,764 outputs
Outputs from Virology
#52
of 9,507 outputs
Outputs of similar age
#7,584
of 279,328 outputs
Outputs of similar age from Virology
#4
of 97 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,507 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.