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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Gut Microbiota Composition in Dichorionic Triplet Sets Suggests a Role for Host Genetic Factors
|
|---|---|
| Published in |
PLOS ONE, April 2015
|
| DOI | 10.1371/journal.pone.0122561 |
| Pubmed ID | |
| Authors |
Kiera Murphy, Carol Anne O’ Shea, C. Anthony Ryan, Eugene M. Dempsey, Paul W. O' Toole, Catherine Stanton, R. Paul Ross |
| Abstract |
Monozygotic and dizygotic twin studies investigating the relative roles of host genetics and environmental factors in shaping gut microbiota composition have produced conflicting results. In this study, we investigated the gut microbiota composition of a healthy dichorionic triplet set. The dichorionic triplet set contained a pair of monozygotic twins and a fraternal sibling, with similar pre- and post-natal environmental conditions including feeding regime. V4 16S rRNA and rpoB amplicon pyrosequencing was employed to investigate microbiota composition, and the species and strain diversity of the culturable bifidobacterial population was also examined. At month 1, the monozygotic pair shared a similar microbiota distinct to the fraternal sibling. By month 12 however, the profile was more uniform between the three infants. Principal coordinate analysis (PCoA) of the microbiota composition revealed strong clustering of the monozygotic pair at month 1 and a separation of the fraternal infant. At months 2 and 3 the phylogenetic distance between the monozygotic pair and the fraternal sibling has greatly reduced and by month 12 the monozygotic pair no longer clustered separately from the fraternal infant. Pulse field gel electrophoresis (PFGE) analysis of the bifidobacterial population revealed a lack of strain diversity, with identical strains identified in all three infants at month 1 and 12. The microbiota of two antibiotic-treated dichorionic triplet sets was also investigated. Not surprisingly, in both triplet sets early life antibiotic administration appeared to be a major determinant of microbiota composition at month 1, irrespective of zygosity. By month 12, early antibiotic administration appeared to no longer exert such a strong influence on gut microbiota composition. We hypothesize that initially host genetics play a significant role in the composition of an individual's gut microbiota, unless an antibiotic intervention is given, but by month 12 environmental factors are the major determinant. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 11% |
| Ireland | 1 | 5% |
| Australia | 1 | 5% |
| Cameroon | 1 | 5% |
| Denmark | 1 | 5% |
| United States | 1 | 5% |
| Unknown | 12 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 8 | 42% |
| Members of the public | 8 | 42% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 97 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 19% |
| Student > Ph. D. Student | 16 | 16% |
| Student > Master | 13 | 13% |
| Student > Doctoral Student | 7 | 7% |
| Student > Bachelor | 7 | 7% |
| Other | 17 | 17% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 19% |
| Medicine and Dentistry | 19 | 19% |
| Biochemistry, Genetics and Molecular Biology | 10 | 10% |
| Immunology and Microbiology | 8 | 8% |
| Nursing and Health Professions | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 21 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2016.
All research outputs
#3,277,059
of 24,885,505 outputs
Outputs from PLOS ONE
#43,752
of 215,531 outputs
Outputs of similar age
#41,014
of 269,636 outputs
Outputs of similar age from PLOS ONE
#1,087
of 6,880 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 215,531 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,636 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 6,880 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.