| Title |
Ghrelin and PYY levels in adolescents with severe obesity: effects of weight loss induced by long-term exercise training and modified food habits
|
|---|---|
| Published in |
European Journal of Applied Physiology, September 2011
|
| DOI | 10.1007/s00421-011-2154-2 |
| Pubmed ID | |
| Authors |
Carine Gueugnon, Fabienne Mougin, Nhu Uyen Nguyen, Malika Bouhaddi, Marie Nicolet-Guénat, Gilles Dumoulin |
| Abstract |
This study investigated (a) changes in ghrelin and peptide YY (PYY) concentrations during a weight reduction programme and (b) baseline ghrelin and PYY levels as predictors of weight loss in 32 severely obese adolescents (BMI z score = 4.1). Subjects spent an academic year in an institution for childhood obesity. Fasting ghrelin and PYY, leptin, insulin levels and insulin resistance were measured at baseline (month 0) and during the programme (months 3, 6, 9). In addition, 15 normal-weight teenagers served as reference for the baseline assessments. At baseline, obese teenagers had lower ghrelin and PYY concentrations than normal-weight adolescents (P < 0.05). Moreover, they showed significantly higher leptin, insulin levels and homeostasis model assessment (HOMA) (P < 0.0001). During the lifestyle modification, there was a significant decrease in body weight among obese teenagers, associated with an increase in ghrelin (apparent from month 6; P < 0.05), a decrease in leptin (from month 3; P < 0.05) and a decrease in insulin and HOMA (from month 3; P < 0.0001), without any significant change in PYY. Anthropometrical changes were correlated neither with baseline ghrelin levels nor with changes in ghrelin and PYY after the lifestyle modification. However, higher baseline PYY tended to correlate with greater anthropometrical changes (P < 0.1). In adolescents with severe obesity, a long-term combination of supervised aerobic exercises and a balanced diet led to weight reduction and increased ghrelin concentrations, without any change in PYY concentrations. Moreover, baseline PYY concentrations might be considered as predictors of weight loss. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 17% |
| Student > Bachelor | 10 | 12% |
| Researcher | 8 | 10% |
| Student > Postgraduate | 5 | 6% |
| Student > Ph. D. Student | 5 | 6% |
| Other | 16 | 20% |
| Unknown | 24 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 15 | 18% |
| Medicine and Dentistry | 12 | 15% |
| Agricultural and Biological Sciences | 7 | 9% |
| Nursing and Health Professions | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 29 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2011.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from European Journal of Applied Physiology
#4,069
of 4,345 outputs
Outputs of similar age
#126,178
of 136,929 outputs
Outputs of similar age from European Journal of Applied Physiology
#63
of 66 outputs
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