| Title |
Peripheral Blood Cell Interactions of Cancer-Derived Exosomes Affect Immune Function
|
|---|---|
| Published in |
Cancer Microenvironment, March 2018
|
| DOI | 10.1007/s12307-018-0209-1 |
| Pubmed ID | |
| Authors |
Heather R. Ferguson Bennit, Amber Gonda, James R. W. McMullen, Janviere Kabagwira, Nathan R. Wall |
| Abstract |
Cancer-derived exosomes are constitutively produced and secreted into the blood and biofluids of their host patients providing a liquid biopsy for early detection and diagnosis. Given their ubiquitous nature, cancer exosomes influence biological mechanisms that are beneficial to the tumor cells where they are produced and the microenvironment in which these tumors exist. Accumulating evidence suggests that exosomes transport proteins, lipids, DNA, mRNA, miRNA and long non coding RNA (lncRNA) for the purpose of cell-cell and cell-extracellular communication. These exosomes consistently reflect the status as well as identity of their cell of origin and as such may conceivably be affecting the ability of a functional immune system to recognize and eliminate cancer cells. Recognizing and mapping the pathways in which immune suppression is garnered through these tumor derived exosome (TEX) may lead to treatment strategies in which specific cell membrane proteins or receptors may be targeted, allowing for immune surveillance to once again help with the treatment of cancer. This Review focuses on how cancer exosomes interact with immune cells in the blood. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 6 | 19% |
| Student > Master | 4 | 13% |
| Student > Ph. D. Student | 4 | 13% |
| Student > Bachelor | 3 | 9% |
| Researcher | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 10 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 28% |
| Immunology and Microbiology | 3 | 9% |
| Neuroscience | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 10 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2019.
All research outputs
#14,389,551
of 23,045,021 outputs
Outputs from Cancer Microenvironment
#59
of 92 outputs
Outputs of similar age
#187,073
of 329,485 outputs
Outputs of similar age from Cancer Microenvironment
#3
of 4 outputs
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So far Altmetric has tracked 92 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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