| Title |
Drug dosing and monitoring in obese patients undergoing allogenic stem cell transplantation
|
|---|---|
| Published in |
International Journal of Clinical Pharmacy, September 2011
|
| DOI | 10.1007/s11096-011-9568-0 |
| Pubmed ID | |
| Authors |
Claudia Langebrake, Friederike Bernhardt, Michael Baehr, Nicolaus Kröger, Axel R. Zander |
| Abstract |
The effects of physiological changes in patients with obesity on pharmacokinetic parameters and the time course of drug response, especially in the field of haematology/oncology, are poorly understood. For some antimicrobial drugs, dosing considerations exist, while for cytostatic drugs, dose modifications for obese patients are not consistently recommended. Glomerular filtration rate and renal perfusion appear to be similar in obese and normal weight individuals, thus elimination of hydrophilic and extensively renally cleared drugs mainly depends upon creatinine clearance. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 31 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 9 | 27% |
| Researcher | 4 | 12% |
| Professor | 3 | 9% |
| Student > Postgraduate | 3 | 9% |
| Student > Ph. D. Student | 3 | 9% |
| Other | 5 | 15% |
| Unknown | 6 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 58% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 15% |
| Nursing and Health Professions | 2 | 6% |
| Agricultural and Biological Sciences | 1 | 3% |
| Unknown | 6 | 18% |