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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation
|
|---|---|
| Published in |
Cell Stem Cell, April 2015
|
| DOI | 10.1016/j.stem.2015.03.007 |
| Pubmed ID | |
| Authors |
Yafei Yin, Pixi Yan, Jinlong Lu, Guang Song, Yangyang Zhu, Zhaohui Li, Yi Zhao, Bin Shen, Xingxu Huang, Heng Zhu, Stuart H. Orkin, Xiaohua Shen |
| Abstract |
Long noncoding RNAs (lncRNAs) have been implicated in controlling various aspects of embryonic stem cell (ESC) biology, although the functions of specific lncRNAs, and the molecular mechanisms through which they act, remain unclear. Here, we demonstrate discrete and opposing roles for the lncRNA transcript Haunt and its genomic locus in regulating the HOXA gene cluster during ESC differentiation. Reducing or enhancing Haunt expression, with minimal disruption of the Haunt locus, led to upregulation or downregulation of HOXA genes, respectively. In contrast, increasingly large genomic deletions within the Haunt locus attenuated HOXA activation. The Haunt DNA locus contains potential enhancers of HOXA activation, whereas Haunt RNA acts to prevent aberrant HOXA expression. This work reveals a multifaceted model of lncRNA-mediated transcriptional regulation of the HOXA cluster, with distinct roles for a lncRNA transcript and its genomic locus, while illustrating the power of rapid CRISPR/Cas9-based genome editing for assigning lncRNA functions. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 30% |
| France | 3 | 11% |
| United Kingdom | 2 | 7% |
| India | 1 | 4% |
| Switzerland | 1 | 4% |
| China | 1 | 4% |
| Canada | 1 | 4% |
| Unknown | 10 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 44% |
| Scientists | 12 | 44% |
| Science communicators (journalists, bloggers, editors) | 3 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 289 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 1% |
| United Kingdom | 3 | 1% |
| Netherlands | 1 | <1% |
| Finland | 1 | <1% |
| Israel | 1 | <1% |
| France | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Canada | 1 | <1% |
| Denmark | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 275 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 76 | 26% |
| Researcher | 61 | 21% |
| Student > Master | 40 | 14% |
| Student > Bachelor | 28 | 10% |
| Student > Doctoral Student | 11 | 4% |
| Other | 36 | 12% |
| Unknown | 37 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 110 | 38% |
| Biochemistry, Genetics and Molecular Biology | 109 | 38% |
| Medicine and Dentistry | 11 | 4% |
| Immunology and Microbiology | 7 | 2% |
| Neuroscience | 4 | 1% |
| Other | 6 | 2% |
| Unknown | 42 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2023.
All research outputs
#1,426,443
of 25,373,627 outputs
Outputs from Cell Stem Cell
#935
of 2,823 outputs
Outputs of similar age
#16,957
of 262,386 outputs
Outputs of similar age from Cell Stem Cell
#13
of 37 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.