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Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

Overview of attention for article published in Neurobiology of Aging, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

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1 news outlet
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3 X users
patent
1 patent

Citations

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125 Dimensions

Readers on

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99 Mendeley
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Title
Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease
Published in
Neurobiology of Aging, April 2015
DOI 10.1016/j.neurobiolaging.2015.04.005
Pubmed ID
Authors

Joannee Zumkehr, Carlos J. Rodriguez-Ortiz, David Cheng, Zanett Kieu, Thin Wai, Charlesice Hawkins, Jason Kilian, Siok Lam Lim, Rodrigo Medeiros, Masashi Kitazawa

Abstract

Glial glutamate transporter, GLT-1, is the major Na(+)-driven glutamate transporter to control glutamate levels in synapses and prevent glutamate-induced excitotoxicity implicated in neurodegenerative disorders including Alzheimer's disease (AD). Significant functional loss of GLT-1 has been reported to correlate well with synaptic degeneration and severity of cognitive impairment among AD patients, yet the underlying molecular mechanism and its pathological consequence in AD are not well understood. Here, we find the temporal decrease in GLT-1 levels in the hippocampus of the 3xTg-AD mouse model and that the pharmacological upregulation of GLT-1 significantly ameliorates the age-dependent pathological tau accumulation, restores synaptic proteins, and rescues cognitive decline with minimal effects on Aβ pathology. In primary neuron and astrocyte coculture, naturally secreted Aβ species significantly downregulate GLT-1 steady-state and expression levels. Taken together, our data strongly suggest that GLT-1 restoration is neuroprotective and Aβ-induced astrocyte dysfunction represented by a functional loss of GLT-1 may serve as one of the major pathological links between Aβ and tau pathology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Spain 1 1%
Unknown 96 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 19%
Researcher 16 16%
Student > Master 13 13%
Student > Bachelor 13 13%
Professor > Associate Professor 5 5%
Other 13 13%
Unknown 20 20%
Readers by discipline Count As %
Neuroscience 30 30%
Agricultural and Biological Sciences 16 16%
Biochemistry, Genetics and Molecular Biology 8 8%
Medicine and Dentistry 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 5 5%
Unknown 27 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2020.
All research outputs
#2,377,152
of 25,374,647 outputs
Outputs from Neurobiology of Aging
#508
of 4,418 outputs
Outputs of similar age
#28,321
of 262,392 outputs
Outputs of similar age from Neurobiology of Aging
#13
of 56 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,392 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.