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Mendeley readers
Attention Score in Context
| Title |
ATM kinase sustains HER2 tumorigenicity in breast cancer
|
|---|---|
| Published in |
Nature Communications, April 2015
|
| DOI | 10.1038/ncomms7886 |
| Pubmed ID | |
| Authors |
Venturina Stagni, Isabella Manni, Veronica Oropallo, Marcella Mottolese, Anna Di Benedetto, Giulia Piaggio, Rita Falcioni, Danilo Giaccari, Selene Di Carlo, Francesca Sperati, Maria Teresa Cencioni, Daniela Barilà |
| Abstract |
ATM kinase preserves genomic stability by acting as a tumour suppressor. However, its identification as a component of several signalling networks suggests a dualism for ATM in cancer. Here we report that ATM expression and activity promotes HER2-dependent tumorigenicity in vitro and in vivo. We reveal a correlation between ATM activation and the reduced time to recurrence in patients diagnosed with invasive HER2-positive breast cancer. Furthermore, we identify ATM as a novel modulator of HER2 protein stability that acts by promoting a complex of HER2 with the chaperone HSP90, therefore preventing HER2 ubiquitination and degradation. As a consequence, ATM sustains AKT activation downstream of HER2 and may modulate the response to therapeutic approaches, suggesting that the status of ATM activity may be informative for the treatment and prognosis of HER2-positive tumours. Our findings provide evidence for ATM's tumorigenic potential revising the canonical role of ATM as a pure tumour suppressor. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 61 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 23% |
| Researcher | 11 | 18% |
| Student > Bachelor | 10 | 16% |
| Student > Master | 6 | 10% |
| Student > Postgraduate | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 13 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 23% |
| Biochemistry, Genetics and Molecular Biology | 14 | 23% |
| Medicine and Dentistry | 9 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Immunology and Microbiology | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 14 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2015.
All research outputs
#20,268,102
of 22,799,071 outputs
Outputs from Nature Communications
#45,543
of 46,928 outputs
Outputs of similar age
#200,933
of 237,938 outputs
Outputs of similar age from Nature Communications
#730
of 767 outputs
Altmetric has tracked 22,799,071 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 46,928 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,938 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 767 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.