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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide‑1 Receptor (GLP-1R) Agonists
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, April 2015
|
| DOI | 10.1021/acs.jmedchem.5b00166 |
| Pubmed ID | |
| Authors |
Huy N. Hoang, Kun Song, Timothy A. Hill, David R. Derksen, David J. Edmonds, W. Mei Kok, Chris Limberakis, Spiros Liras, Paula M. Loria, Vincent Mascitti, Alan M. Mathiowetz, Justin M. Mitchell, David W. Piotrowski, David A. Price, Robert V. Stanton, Jacky Y. Suen, Jane M. Withka, David A. Griffith, David P. Fairlie |
| Abstract |
Cyclic constraints are incorporated here into an 11-residue analogue of the N-terminus of glucagon-like peptide-1 (GLP-1) to investigate effects of structure on agonist activity. Cyclization through linking side chains of residues 2 and 5 or 5 and 9 produced agonists at nM concentrations in a cAMP assay. 2D-NMR and CD spectra revealed an N-terminal β-turn and a C-terminal helix that differentially influenced affinity and agonist potency. These structures can inform development of small molecule agonists of the GLP-1 receptor to treat type 2 diabetes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 25% |
| Researcher | 11 | 20% |
| Student > Doctoral Student | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 4 | 7% |
| Other | 7 | 13% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 30 | 54% |
| Agricultural and Biological Sciences | 6 | 11% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Medicine and Dentistry | 2 | 4% |
| Other | 0 | 0% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2020.
All research outputs
#3,687,832
of 22,799,071 outputs
Outputs from Journal of Medicinal Chemistry
#5,912
of 22,067 outputs
Outputs of similar age
#43,626
of 237,938 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#35
of 124 outputs
Altmetric has tracked 22,799,071 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,067 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,938 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.