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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SORL1 Gene is Associated with the Conversion from Mild Cognitive Impairment to Alzheimer’s Disease
|
|---|---|
| Published in |
Journal of Alzheimer's Disease, January 2015
|
| DOI | 10.3233/jad-141551 |
| Pubmed ID | |
| Authors |
Paola Piscopo, Giuseppe Tosto, Chiara Belli, Giuseppina Talarico, Daniela Galimberti, Marina Gasparini, Marco Canevelli, Anna Poleggi, Alessio Crestini, Diego Albani, Gianluigi Forloni, Ugo Lucca, Pierluigi Quadri, Mauro Tettamanti, Chiara Fenoglio, Elio Scarpini, Giuseppe Bruno, Nicola Vanacore, Annamaria Confaloni |
| Abstract |
Several studies have established the sortilin-related receptor gene (SORL1) as a susceptibility locus for Alzheimer's disease (AD). Single nucleotide polymorphisms of SORL1 reported in literature as being associated with AD were investigated in an Italian case-control data set, and their role as a risk factor of conversion to AD was studied in an independent sample of subjects diagnosed with mild cognitive impairment (MCI) at baseline. rs641120, rs2070045, and rs1010159 were genotyped in 734 subjects diagnosed with AD (n = 338) and MCI (n = 181) and in healthy controls (n = 215). Our results confirmed the association between rs641120 and AD (p = 0.01). In the MCI cohort, rs1010159 was associated with conversion to AD (HR = 1.56, p = 0.002). Taken together, these findings confirm that SORL1 is associated with AD and might be a potential tool for identifying MCI subjects at high risk of conversion to AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 24% |
| Student > Bachelor | 6 | 12% |
| Student > Ph. D. Student | 3 | 6% |
| Professor > Associate Professor | 3 | 6% |
| Other | 2 | 4% |
| Other | 8 | 16% |
| Unknown | 17 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 20% |
| Medicine and Dentistry | 6 | 12% |
| Neuroscience | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Psychology | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 18 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2016.
All research outputs
#2,811,734
of 25,374,917 outputs
Outputs from Journal of Alzheimer's Disease
#1,486
of 7,452 outputs
Outputs of similar age
#37,681
of 359,530 outputs
Outputs of similar age from Journal of Alzheimer's Disease
#84
of 449 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,452 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,530 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 449 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.