| Title |
Evidence of altered autonomic cardiac regulation in breast cancer survivors
|
|---|---|
| Published in |
Journal of Cancer Survivorship, April 2015
|
| DOI | 10.1007/s11764-015-0445-z |
| Pubmed ID | |
| Authors |
Chiara Vigo, Wolfgang Gatzemeier, Roberto Sala, Mara Malacarne, Armando Santoro, Massimo Pagani, Daniela Lucini |
| Abstract |
Surgery and adjuvant therapy improved prognosis of breast cancer survivors. This improvement risks being offset by potential late-occurring cardiovascular toxicity of oncologic treatment and increased cardiometabolic risk profile associated with lifestyle changes. We address the hypothesis that in breast cancer survivors, multiple functional alterations might define a phenotype, characterized by vagal impairment, diminished aerobic fitness, increased metabolic risk, and reduced wellbeing. We studied 171 sedentary asymptomatic women (106 cancer survivor-65 controls) of similar age (53 ± 8.6; 51 ± 8.1 years). Autonomic regulation was evaluated by autoregressive spectral analysis of R wave to R wave (RR) interval and systolic arterial pressure variability. Aerobic fitness was directly assessed by cardiopulmonary exercise test. Body mass index (BMI) and waist circumference served as proxies of metabolism. Fatigue and stress-related symptoms were evaluated with validated questionnaire. Patients showed significantly smaller total RR variance (1644 ± 2363 vs 2302 ± 1561 msec(2)), smaller absolute power of low frequency (LF) (386 ± 745 vs 810 ± 1300 msec(2)) and high frequency (HF) (485 ± 1202 vs 582 ± 555 msec(2)) of RR interval variability and smaller spontaneous baroreflex sensitivity (15.0 ± 8.9 vs 21.9 ± 10 msec/mmHg), suggesting vagal impairment. VO2 peak and O2 pulse were lower in cancer survivors than in controls. Fatigue and stress-related somatic symptoms scores were higher, as was BMI and waist circumference. Breast cancer survivors show multiple dysfunctions: vagal impairment, lower aerobic fitness, signs of altered metabolism, and higher perception of fatigue. We propose that the concept of clinical phenotype, which may accommodate multiple functional disturbances, might be useful in long-term personalized prevention programs for breast cancer survivors. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 3 | 38% |
| United Kingdom | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 112 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 17% |
| Student > Bachelor | 17 | 15% |
| Student > Ph. D. Student | 16 | 14% |
| Researcher | 9 | 8% |
| Student > Doctoral Student | 5 | 4% |
| Other | 16 | 14% |
| Unknown | 31 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 22% |
| Nursing and Health Professions | 18 | 16% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Psychology | 8 | 7% |
| Sports and Recreations | 7 | 6% |
| Other | 14 | 12% |
| Unknown | 32 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2015.
All research outputs
#6,287,079
of 23,613,071 outputs
Outputs from Journal of Cancer Survivorship
#445
of 1,028 outputs
Outputs of similar age
#72,005
of 266,372 outputs
Outputs of similar age from Journal of Cancer Survivorship
#8
of 22 outputs
Altmetric has tracked 23,613,071 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,028 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,372 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.