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Transient and Partial Nuclear Lamina Disruption Promotes Chromosome Movement in Early Meiotic Prophase

Overview of attention for article published in Developmental Cell, April 2018
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  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Average Attention Score compared to outputs of the same age and source

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76 Mendeley
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Title
Transient and Partial Nuclear Lamina Disruption Promotes Chromosome Movement in Early Meiotic Prophase
Published in
Developmental Cell, April 2018
DOI 10.1016/j.devcel.2018.03.018
Pubmed ID
Authors

Jana Link, Dimitra Paouneskou, Maria Velkova, Anahita Daryabeigi, Triin Laos, Sara Labella, Consuelo Barroso, Sarai Pacheco Piñol, Alex Montoya, Holger Kramer, Alexander Woglar, Antoine Baudrimont, Sebastian Mathias Markert, Christian Stigloher, Enrique Martinez-Perez, Alexander Dammermann, Manfred Alsheimer, Monique Zetka, Verena Jantsch

Abstract

Meiotic chromosome movement is important for the pairwise alignment of homologous chromosomes, which is required for correct chromosome segregation. Movement is driven by cytoplasmic forces, transmitted to chromosome ends by nuclear membrane-spanning proteins. In animal cells, lamins form a prominent scaffold at the nuclear periphery, yet the role lamins play in meiotic chromosome movement is unclear. We show that chromosome movement correlates with reduced lamin association with the nuclear rim, which requires lamin phosphorylation at sites analogous to those that open lamina network crosslinks in mitosis. Failure to remodel the lamina results in delayed meiotic entry, altered chromatin organization, unpaired or interlocked chromosomes, and slowed chromosome movement. The remodeling kinases are delivered to lamins via chromosome ends coupled to the nuclear envelope, potentially enabling crosstalk between the lamina and chromosomal events. Thus, opening the lamina network plays a role in modulating contacts between chromosomes and the nuclear periphery during meiosis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 26%
Researcher 14 18%
Student > Master 8 11%
Student > Bachelor 7 9%
Student > Doctoral Student 4 5%
Other 10 13%
Unknown 13 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 33 43%
Agricultural and Biological Sciences 19 25%
Medicine and Dentistry 2 3%
Nursing and Health Professions 1 1%
Business, Management and Accounting 1 1%
Other 4 5%
Unknown 16 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2018.
All research outputs
#7,310,578
of 25,397,764 outputs
Outputs from Developmental Cell
#2,385
of 4,319 outputs
Outputs of similar age
#120,259
of 343,842 outputs
Outputs of similar age from Developmental Cell
#48
of 71 outputs
Altmetric has tracked 25,397,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,319 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.1. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.