| Title |
Ciliary proteins Fap43 and Fap44 interact with each other and are essential for proper cilia and flagella beating
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, April 2018
|
| DOI | 10.1007/s00018-018-2819-7 |
| Pubmed ID | |
| Authors |
Paulina Urbanska, Ewa Joachimiak, Rafał Bazan, Gang Fu, Martyna Poprzeczko, Hanna Fabczak, Daniela Nicastro, Dorota Wloga |
| Abstract |
Cilia beating is powered by the inner and outer dynein arms (IDAs and ODAs). These multi-subunit macrocomplexes are arranged in two rows on each outer doublet along the entire cilium length, except its distal end. To generate cilia beating, the activity of ODAs and IDAs must be strictly regulated locally by interactions with the dynein arm-associated structures within each ciliary unit and coordinated globally in time and space between doublets and along the axoneme. Here, we provide evidence of a novel ciliary complex composed of two conserved WD-repeat proteins, Fap43p and Fap44p. This complex is adjacent to another WD-repeat protein, Fap57p, and most likely the two-headed inner dynein arm, IDA I1. Loss of either protein results in altered waveform, beat stroke and reduced swimming speed. The ciliary localization of Fap43p and Fap44p is interdependent in the ciliate Tetrahymena thermophila. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 31% |
| Researcher | 8 | 25% |
| Student > Master | 5 | 16% |
| Professor | 2 | 6% |
| Student > Bachelor | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 44% |
| Agricultural and Biological Sciences | 9 | 28% |
| Medicine and Dentistry | 1 | 3% |
| Chemistry | 1 | 3% |
| Unknown | 7 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2018.
All research outputs
#19,201,293
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,458
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Outputs of similar age
#255,739
of 328,021 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#33
of 43 outputs
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