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Reference intervals for plasma sulfate and urinary sulfate excretion in pregnancy

Overview of attention for article published in BMC Pregnancy and Childbirth, April 2015
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Title
Reference intervals for plasma sulfate and urinary sulfate excretion in pregnancy
Published in
BMC Pregnancy and Childbirth, April 2015
DOI 10.1186/s12884-015-0526-z
Pubmed ID
Authors

Paul Anthony Dawson, Scott Petersen, Robyn Rodwell, Phillip Johnson, Kristen Gibbons, Avis McWhinney, Francis Gerard Bowling, Harold David McIntyre

Abstract

Sulfate is important for fetal growth and development. During pregnancy, the fetus relies on sulfate from the maternal circulation. We report reference intervals for maternal plasma sulfate levels and fractional excretion index (FEI) for sulfate in pregnancy, as well as sulfate levels in cord blood from term pregnancies. Plasma and urine were collected from 103 pregnant women of 10-20 weeks gestation and 106 pregnant women of 30-37 weeks gestation. Venous cord plasma was collected from 80 healthy term babies. Sulfate levels were measured by ion chromatography. Plasma and urinary creatinine levels were used to calculate FEI sulfate in pregnant women. Analyses provide reference intervals, and explored the relationship between maternal sulfate data with several prenatal factors. Median maternal plasma sulfate levels were 452 μmol/L and 502 μmol/L at 10-20 and 30-37 weeks gestation, respectively, and inversely correlated with FEI sulfate median values of 0.15 and 0.11. Overall reference intervals were 305-710 and 335-701 μmol/L (2.5th; 97.5th percentile; for 10-20 and 30-37 weeks gestation, respectively) for maternal plasma sulfate, and 0.06-0.31 and 0.05-0.28 for maternal FEI sulfate. Term venous cord plasma sulfate median levels were significantly (p = 0.038) higher in female babies (375 μmol/L) when compared to male babies (342 μmol/L), with an overall reference interval of 175-603 μmol/L. We provide the first reference intervals for maternal plasma sulfate levels and FEI sulfate, as well as cord plasma sulfate levels. These findings provide reference data for further studies of sulfate levels in both mother and child.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Student > Master 4 19%
Student > Bachelor 2 10%
Researcher 1 5%
Student > Postgraduate 1 5%
Other 0 0%
Unknown 8 38%
Readers by discipline Count As %
Medicine and Dentistry 7 33%
Agricultural and Biological Sciences 3 14%
Psychology 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Unknown 9 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2015.
All research outputs
#20,880,816
of 25,654,806 outputs
Outputs from BMC Pregnancy and Childbirth
#3,978
of 4,838 outputs
Outputs of similar age
#208,078
of 280,303 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#68
of 78 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.