| Title |
Heart Rate Variability and Cardiopulmonary Dysfunction in Patients with Duchenne Muscular Dystrophy: A Systematic Review
|
|---|---|
| Published in |
Pediatric Cardiology, April 2018
|
| DOI | 10.1007/s00246-018-1881-0 |
| Pubmed ID | |
| Authors |
Talita Dias da Silva, Thais Massetti, Tânia Brusque Crocetta, Carlos Bandeira de Mello Monteiro, Alex Carll, Luiz Carlos Marques Vanderlei, Carlie Arbaugh, Fernando Rocha Oliveira, Luiz Carlos de Abreu, Celso Ferreira Filho, John Godleski, Celso Ferreira |
| Abstract |
Duchenne muscular dystrophy (DMD) is a genetic recessive disorder with progressive muscle weakness. Despite the general muscle wasting, degeneration and necrosis of cardiomyocytes have been the main causes of morbidity and death in individuals with DMD. Cardiac failure is generally preceded by disturbances in heart rate variability (HRV), and non-invasive measurement of the autonomic nervous system has been an important tool to predict adverse cardiovascular events. Hence, the application of HRV to study autonomic modulation in DMD individuals, and the establishment of correlations between HRV and heart/lung diseases, age, and mortality will have the potential to improve quality of life and life expectancy of individuals with DMD. In order to evaluate the state of the art in this field, we conducted a systematic search in Medline/PubMed and BVS (virtual library in health) databases. We selected 8 studies using pre-defined criteria and meta-analysis revealed decreased parasympathetic activity and increased sympathetic predominance in individuals with DMD as major observations. Moreover, there is a strong association between diminished HRV and myocardial fibrosis with DMD. These patterns are evident in patients at early-stage DMD and become more prominent as disease severity and age increase. Thus, data minning clearly indicates that HRV assessment can be used as a predictor for sudden death in individuals with DMD. The use of the HRV, which is inexpensive, ubiquitously available in clinics and hospitals, and a non-invasive analysis tool, can save lives and decrease the morbity in DMD by alerting care givers to consider autonomic nervous system intervention. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 14% |
| Student > Master | 14 | 14% |
| Researcher | 12 | 12% |
| Student > Bachelor | 8 | 8% |
| Student > Doctoral Student | 6 | 6% |
| Other | 18 | 18% |
| Unknown | 29 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 27% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Nursing and Health Professions | 7 | 7% |
| Sports and Recreations | 6 | 6% |
| Neuroscience | 4 | 4% |
| Other | 15 | 15% |
| Unknown | 34 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2018.
All research outputs
#14,852,402
of 23,045,021 outputs
Outputs from Pediatric Cardiology
#610
of 1,415 outputs
Outputs of similar age
#194,889
of 326,539 outputs
Outputs of similar age from Pediatric Cardiology
#11
of 38 outputs
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So far Altmetric has tracked 1,415 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.