Title |
Rickets
|
---|---|
Published in |
Current Osteoporosis Reports, October 2011
|
DOI | 10.1007/s11914-011-0081-0 |
Pubmed ID | |
Authors |
M. Zulf Mughal |
Abstract |
Rickets is disorder of a growing child arising from disorders that result in impaired apoptosis of hypertrophic cells and mineralization of the growth plate. Rickets due to nutritional causes remains an important global problem. The factors responsible for resurgence of rickets among dark-skinned infants living in developed countries include the following: residence in northern or southern latitudes, voluntary avoidance of exposure to solar ultraviolet B radiation, maternal vitamin D deficiency during pregnancy, and prolonged breastfeeding without provision of vitamin D supplements. Fibroblast growth factor 23 (FGF23), secreted by osteocytes, is an important regulator of serum phosphate and 1,25(OH)(2)D(3) levels. Hypophosphatemic rickets resulting from increased synthesis or under-catabolism of FGF23 is reviewed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 90 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 18% |
Student > Master | 12 | 13% |
Researcher | 9 | 10% |
Student > Postgraduate | 8 | 9% |
Other | 6 | 7% |
Other | 9 | 10% |
Unknown | 31 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 34 | 37% |
Agricultural and Biological Sciences | 7 | 8% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Nursing and Health Professions | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 8 | 9% |
Unknown | 29 | 32% |