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Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle

Overview of attention for article published in Cell Death & Disease, April 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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2 news outlets
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1 blog
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3 X users
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2 patents

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136 Mendeley
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Title
Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle
Published in
Cell Death & Disease, April 2015
DOI 10.1038/cddis.2015.79
Pubmed ID
Authors

N Arrighi, C Moratal, N Clément, S Giorgetti-Peraldi, P Peraldi, A Loubat, J-Y Kurzenne, C Dani, A Chopard, C A Dechesne

Abstract

A population of fibro/adipogenic but non-myogenic progenitors located between skeletal muscle fibers was recently discovered. The aim of this study was to determine the extent to which these progenitors differentiate into fully functional adipocytes. The characterization of muscle progenitor-derived adipocytes is a central issue in understanding muscle homeostasis. They are considered as being the cellular origin of intermuscular adipose tissue that develops in several pathophysiological situations. Here fibro/adipogenic progenitors were isolated from a panel of 15 human muscle biopsies on the basis of the specific cell-surface immunophenotype CD15(+)/PDGFRα(+)CD56(-). This allowed investigations of their differentiation into adipocytes and the cellular functions of terminally differentiated adipocytes. Adipogenic differentiation was found to be regulated by the same effectors as those regulating differentiation of progenitors derived from white subcutaneous adipose tissue. Similarly, basic adipocyte functions, such as triglyceride synthesis and lipolysis occurred at levels similar to those observed with subcutaneous adipose tissue progenitor-derived adipocytes. However, muscle progenitor-derived adipocytes were found to be insensitive to insulin-induced glucose uptake, in association with the impairment of phosphorylation of key insulin-signaling effectors. Our findings indicate that muscle adipogenic progenitors give rise to bona fide white adipocytes that have the unexpected feature of being insulin-resistant.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 136 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 23%
Student > Bachelor 16 12%
Researcher 15 11%
Student > Master 15 11%
Student > Doctoral Student 11 8%
Other 17 13%
Unknown 31 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 49 36%
Agricultural and Biological Sciences 23 17%
Medicine and Dentistry 9 7%
Engineering 7 5%
Sports and Recreations 4 3%
Other 6 4%
Unknown 38 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2023.
All research outputs
#1,142,840
of 23,267,128 outputs
Outputs from Cell Death & Disease
#98
of 6,599 outputs
Outputs of similar age
#15,351
of 266,367 outputs
Outputs of similar age from Cell Death & Disease
#1
of 101 outputs
Altmetric has tracked 23,267,128 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,599 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.