| Title |
NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: screening in 1969 patients with various cancers
|
|---|---|
| Published in |
Journal of Gastroenterology, April 2015
|
| DOI | 10.1007/s00535-015-1078-8 |
| Pubmed ID | |
| Authors |
Yoko Oshima, Hideaki Shimada, Satoshi Yajima, Tatsuki Nanami, Kazuyuki Matsushita, Fumio Nomura, Osamu Kainuma, Nobuhiro Takiguchi, Hiroaki Soda, Takeshi Ueda, Toshihiko Iizasa, Naoto Yamamoto, Hiroshi Yamamoto, Matsuo Nagata, Sana Yokoi, Masatoshi Tagawa, Seiko Ohtsuka, Akiko Kuwajima, Akihiro Murakami, Hironori Kaneko |
| Abstract |
Although serum NY-ESO-1 antibodies (s-NY-ESO-1-Abs) have been reported in patients with esophageal carcinoma, this assay system has not been used to study a large series of patients with various other cancers. Serum samples of 1969 cancer patients [esophageal cancer (n = 172), lung cancer (n = 269), hepatocellular carcinoma (n = 91), prostate cancer (n = 358), gastric cancer (n = 313), colorectal cancer (n = 262), breast cancer (n = 365)] and 74 healthy individuals were analyzed using an originally developed enzyme-linked immunosorbent assay system for s-NY-ESO-1-Abs. The optical density cut-off value, determined as the mean plus three standard deviations for serum samples from the healthy controls, was fixed at 0.165. Conventional tumor markers were also evaluated in patients with esophageal carcinoma. The positive rate of s-NY-ESO-1-Abs in patients with esophageal cancer (31 %) was significantly higher than that in the other groups: patients with lung cancer (13 %), patients with hepatocellular carcinoma (11 %), patients with prostate cancer (10 %), patients with gastric cancer (10 %), patients with colorectal cancer (8 %), patients with breast cancer (7 %), and healthy controls (0 %). The positive rate of s-NY-ESO-1-Abs was comparable to that of serum p53 antibodies (33 %), squamous cell carcinoma antigen (36 %), carcinoembryonic antigen (26 %), and CYFRA 21-1 (18 %) and gradually increased with the tumor stage. The positive rate of s-NY-ESO-1-Abs was significantly higher in patients with esophageal cancer than in patients with the other types of cancers. On the basis of its high specificity and sensitivity, even in patients with stage I tumors, s-NY-ESO-1-Abs may be one of the first choices for esophageal cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 19% |
| Student > Bachelor | 8 | 17% |
| Student > Master | 7 | 15% |
| Student > Ph. D. Student | 7 | 15% |
| Student > Doctoral Student | 4 | 8% |
| Other | 5 | 10% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 29% |
| Biochemistry, Genetics and Molecular Biology | 9 | 19% |
| Immunology and Microbiology | 7 | 15% |
| Agricultural and Biological Sciences | 2 | 4% |
| Social Sciences | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 9 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#15,330,127
of 22,800,560 outputs
Outputs from Journal of Gastroenterology
#737
of 1,088 outputs
Outputs of similar age
#157,579
of 265,147 outputs
Outputs of similar age from Journal of Gastroenterology
#7
of 13 outputs
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