| Title |
Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
|
|---|---|
| Published in |
Archives of Toxicology, April 2015
|
| DOI | 10.1007/s00204-015-1517-6 |
| Pubmed ID | |
| Authors |
Melissa A. Bradley-Whitman, Mark A. Lovell |
| Abstract |
Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer's disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have demonstrated increased LPO biomarkers in postmortem brain from subjects with mild cognitive impairment, the earliest clinically detectable phase of dementia and preclinical AD, the earliest detectable pathological phase. Furthermore, multiple LPO biomarkers are elevated in readily accessible biological fluids throughout disease progression. Collectively, these studies demonstrate that LPO is an early feature during disease progression and may be considered a key pathway for targeted therapeutics as well as an enhancer of diagnostic accuracy for early detection of subjects during the prodromal phase. |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Unknown | 135 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 15% |
| Researcher | 17 | 13% |
| Student > Bachelor | 17 | 13% |
| Student > Ph. D. Student | 15 | 11% |
| Student > Doctoral Student | 12 | 9% |
| Other | 23 | 17% |
| Unknown | 32 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 15% |
| Neuroscience | 20 | 15% |
| Biochemistry, Genetics and Molecular Biology | 15 | 11% |
| Agricultural and Biological Sciences | 14 | 10% |
| Chemistry | 11 | 8% |
| Other | 15 | 11% |
| Unknown | 40 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#4,173,376
of 22,800,560 outputs
Outputs from Archives of Toxicology
#393
of 2,638 outputs
Outputs of similar age
#53,224
of 265,112 outputs
Outputs of similar age from Archives of Toxicology
#6
of 27 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,638 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.